The present invention provides a method for preparing nicotinamide mononucleotide (NMN) by bioanalysis. The method includes a step of catalytically reacting a plurality of raw materials including nicotinamide, ATP, and ribose in the presence of nicotinamide phosphoribosyltransferase (Nampt), ribose phosphate pyrophosphokinase, and ribokinase, to prepare the NMN.

The present invention relates to a production method and a production intermediate for guanosine-3′,5′-bisdiphosphate.

Disclosed herein are a liver specific delivery (LSD)-based antiviral prodrug nucleoside cyclophosphate compound and uses thereof. Specifically, this application provides a compound of formula (I), or an isomer, a pharmaceutically acceptable salt, a hydrate, a solvate or a pharmaceutical composition thereof. This application also provides an application of the compound alone or in combination with other antiviral drugs in the treatment for viruses, particularly hepatitis C virus (HCV). ##STR00001##

Provided are compounds compound according to Formula (I), or a pharmaceutically acceptable salt, solvate, coordination complex or prodrug thereof: wherein, R.sup.1 and R.sup.2 are independently selected from (C.sub.1-C.sub.6) alkyl. The compounds have P2X3 receptor or P2X2/3 receptor antagonist activity and are useful for the treatment of diseases and disorders characterized by activation of those receptors.

##STR00001##

Provided are compounds compound according to Formula (I), or a pharmaceutically acceptable salt, solvate, coordination complex or prodrug thereof: wherein, R.sup.1 and R.sup.2 are independently selected from (C.sub.1-C.sub.6) alkyl. The compounds have P2X3 receptor or P2X2/3 receptor antagonist activity and are useful for the treatment of diseases and disorders characterized by activation of those receptors.

##STR00001##

This invention provides a process for making 3-O-allyl-dGTP-PC-Biodopy-FL-510, 3-O-allyl-dATP-PC-ROX, 3-O-allyl-dCTP-PC-Bodipy-650 and 3-O-allyl-dUTP-PC-R6G, and related methods.

This invention provides a process for making 3-O-allyl-dGTP-PC-Biodopy-FL-510, 3-O-allyl-dATP-PC-ROX, 3-O-allyl-dCTP-PC-Bodipy-650 and 3-O-allyl-dUTP-PC-R6G, and related methods.

The invention relates to a method for preparing 3-O-amino-2-deoxyribonucleoside-5-triphosphate. It also relates to a solid support functionalized with at least one N-hydroxyphthalimide moiety and uses thereof for protecting 3-hydroxy group of a 2-deoxyribonucleoside during synthesis of a nucleoside or a derivative thereof.

The invention relates to a method for preparing 3-O-amino-2-deoxyribonucleoside-5-triphosphate. It also relates to a solid support functionalized with at least one N-hydroxyphthalimide moiety and uses thereof for protecting 3-hydroxy group of a 2-deoxyribonucleoside during synthesis of a nucleoside or a derivative thereof.

Described herein are genetic recognition reagents comprising terminal aromatic moieties that bind specifically to a template nucleic acid and concatenate. Also provided are methods of using the genetic recognition reagents, e.g., to treat or diagnose a repeat expansion disorder, such as DMI.