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The invention discloses a molecule for targeting the specific receptors in mitigating breast cancer and prostate cancer. The magic bullet is derived as a small molecule using the molecular modelling technique. The molecule of formula (I) comprises the acid as first chemical moiety, hormone derivative as second chemical moiety and the anticancer agent as third chemical moiety. The acid is citric acid or tartaric acid. The hormone for the molecule of formula (I) is estradiol, genistein, apigenin or dihydroxy testosterone. The drug used is selected from 5-flurouracil, capecitabine, gemcitabine, 6-mercaptopurine or calibridin for treatment of breast cancer and 5-flurouracil for treatment of prostate cancer. The molecule of formula (I) is chemically stable, cost effective, exhibits improved efficacy due to specific target, extended duration of therapeutic activity without inducing any immune reaction.

The present invention is directed to oligonucleotide conjugates, pharmaceutical compositions comprising same and to methods for use thereof, such as for the treatment and/or prevention of a genetic disease, or a viral disease in a subject.

Provided are a compound including a cleavable linker, a use thereof, and an intermediate compound for preparing the same, and more particularly, the compound including a cleavable linker of the present invention may include an active agent (for example, a drug, a toxin, a ligand, a probe for detection, etc.) having a specific function or activity, a SO.sub.2 functional group which is capable of selectively releasing the active agent, and a functional group which triggers a chemical reaction, a physicochemical reaction and/or a biological reaction by external stimulation, and may further include a ligand (for example, oligopeptide, polypeptide, antibody, etc.) having binding specificity for a desired target receptor.

The present invention relates to novel 2-Methoxyestradiol derivatives and their medical use. In particular, the novel derivatives of the present invention are useful for the treatment or prevention of liver or lung fibrosis. Accordingly, the present invention also provides medical uses of the 2-Methoxyestradiol derivatives of the present invention. The present invention also provides a method of treating or preventing liver or lung fibrosis comprising administering an effective amount of the 2-Methoxyestradiol derivatives of the present invention.