This invention is directed to methods of preparing AQX-1125 having the formula:

##STR00001##

This invention is also directed to intermediates utilized in the methods of preparing AQX-1125.

Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, betulinic acid derivaties that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formulas I, II and III:

##STR00001##

These compounds are useful for the treatment of HIV and AIDS.

The invention provides compounds of formula I, II, III, or IV: ##STR00001##
wherein R.sup.1 to R.sup.11, X, and Y have any of the values defined in the specification. The compounds inhibit Na, K-ATPase 4 and are useful as contraceptive agents.

The present disclosure is generally directed to neuroactive 13, 17-substituted steroids as referenced herein, and pharmaceutically acceptable salts thereof, for use as, for example, an anesthetic, and/or in the treatment of disorders relating to GABA function and activity. The present disclosure is further directed to pharmaceutical compositions comprising such compounds.

Described herein are protein steroid conjugates that are useful, for example, for the target-specific delivery of glucocorticoids (GCs) to cells.

The present invention relates to salts of budesonide 21-phosphate with 2 adrenergic agonists, preferably with formoterol, pharmaceutical compositions containing the same and the use thereof in the treatment of respiratory inflammatory pathologies, obstructive pathologies and allergen-induced airway dysfunctions. The invention further relates to the process for preparing said salts.

The present invention relates to salts of budesonide 21-phosphate with 2 adrenergic agonists, preferably with formoterol, pharmaceutical compositions containing the same and the use thereof in the treatment of respiratory inflammatory pathologies, obstructive pathologies and allergen-induced airway dysfunctions. The invention further relates to the process for preparing said salts.

Described herein are protein steroid conjugates that are useful, for example, for the target-specific delivery of glucocorticoids (GCs) to cells.