The invention relates to a method of synthesis of a biopolymer derivative, preferably a chitosan derivative, comprising the formation of a peptide bond. The invention also relates to the biopolymer derivative, and use of the biopolymer derivative, preferably a chitosan derivative. The biopolymer derivative has broad uses in the industry, environmental protection and can be used in pharmaceutical and cosmetic compositions. The invention also relates to a composition for prevention of symptoms of allergy caused by heavy metals, especially palladium, cobalt, chromium and gold, in particular nickel.

The present disclosure provides methods and reagents useful for analyzing protein-protein interfaces such as interfaces between a presenter protein (e.g., a member of the FKBP family, a member of the cyclophilin family, or PIN1) and a target protein. In some embodiments, the target and/or presenter proteins are intracellular proteins. In some embodiments, the target and/or presenter proteins are mammalian proteins.

The present disclosure relates to compositions comprising dihydromyricetin (DHM) and fulvic or humic acid or a combination of both, for preventing, ameliorating or treating the effects of acute alcohol intake in a subject. In some embodiments, the composition may further comprise Opuntia ficus indica (prickly pear) or panax ginseng or S-acetyl glutathione. The composition may be either a single composition or multiple, smaller compositions.

The present invention provides compounds of Formula (I) and (II): (I) (II) wherein R.sup.1, R.sup.2, R.sup.4, R.sup.5, R.sup.6, X and n are as defined herein, and wherein R.sup.3 is hydrogen or a sulfur protecting group. Compounds of Formula (I) and (II), wherein R is hydrogen, may be useful in methods for detecting a reactive metabolite in a sample, e.g., wherein the metabolite is generated from the metabolism of a test compound, and wherein the metabolite and the compound of Formula (I) or (II) react to form a detectable adduct, e.g., detectable by mass spectrometry.

A method for producing -Glu-Val-Gly comprising the step of reacting Val-Gly with a -glutamyl group donor in the presence of a -glutamyltransferase, a microorganism containing the enzyme, or a processed product thereof to generate -Glu-Val-Gly, wherein the -glutamyltransferase consists of a large subunit and a small subunit, and the small subunit has a specific mutation.

Prodrugs (I) and (Ia) of galiellactone, and derivatives thereof, are provided by reacting the parent compound, e.g. galiellactone, with a thiol. Such drugs may be administered orally to treat cancer and other proliferative diseases.

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The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.

The present disclosure provides antibody-drug conjugate (ADC) structures, which include a camptothecine or a camptothecine derivative linked to a polypeptide (e.g., an antibody) through a linker. The disclosure also encompasses compounds and methods for production of such conjugates, as well as methods of using the conjugates.

The present invention relates to a Candida utilis strain having high tripeptide-producing ability and/or alcohol lyase activity and its use.

Disclosed herein are embodiments of compounds that can be used to target glutathione to various target sites, such as cells, mitochondria, and other organelles. Also disclosed herein are embodiments of methods for making and using the compounds. In particular disclosed embodiments, the compounds can be used to treat, ameliorate, and/or prevent diseases or conditions associated with low or reduced glutathione levels, as well as other types of diseases/conditions.