The present invention relates to the field of optical imaging More particularly, it relates to compounds of the cyanine family characterized by improved physico-chemical and biological properties and to their conjugates with biological ligands thereof. The invention also relates to the use of these compounds as optical diagnostic agents in imaging or therapy of solid tumors, to the methods for their preparation and to the compositions comprising them.

In accordance with the present disclosure, macrocyclic compounds have been discovered that bind to PD-L1 and are capable of inhibiting the interaction of PD-L1 with PD-1 and CD80. These macrocyclic compounds exhibit in vitro immunomodulatory efficacy thus making them therapeutic candidates for the treatment of various diseases including cancer and infectious diseases.

In accordance with the present disclosure, macrocyclic compounds have been discovered that bind to PD-L1 and are capable of inhibiting the interaction of PD-L1 with PD-1 and CD80. These macrocyclic compounds exhibit in vitro immunomodulatory efficacy thus making them therapeutic candidates for the treatment of various diseases including cancer and infectious diseases.

The present disclosure provides methods for site-selectively crosslinking payloads to antibodies and other proteins. This can be accomplished using traceless affinity labels designed to label target proteins with bio-orthogonally reactive entities (ORE) using the compositions and methods described herein.

Provided, inter alia, are macrocyclic compounds.

There is described herein, multimers comprising plurality of compounds covalently linked together, the compounds independently being of formula (I).

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There is described herein, multimers comprising plurality of compounds covalently linked together, the compounds independently being of formula (I).

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Absorbent structures for absorbent articles are provided, comprising an absorbent layer with absorbent material containing superabsorbent polymer particles supported by a supporting sheet, and having first and a second substantially longitudinal channel that are free of said superabsorbent polymeric particles, and that comprises one or more adhesive material to immobilize said absorbent material. The channels can provide improved fit and/or liquid acquisition/transportation, and/or improved performance.

There is described herein, multimers comprising a plurality of compounds covalently linked together, the compounds independently being of formula (I).

There is described herein, multimers comprising a plurality of compounds covalently linked together, the compounds independently being of formula (I).