Modified biopolymers, such as, charge-modified biopolymers, cross-linked biopolymers, and cross-linked, charge-modified biopolymers are provided along with methods of producing and using the same.

A modified starch material for biocompatible hemostasis, biocompatible adhesion prevention, tissue healing promotion, absorbable surgical wound sealing and tissue bonding, when applied as a biocompatible modified starch to the tissue of animals. The modified starch material produces hemostasis, reduces bleeding of the wound, extravasation of blood and tissue exudation, preserves the wound surface or the wound in relative wetness or dryness, inhibits the growth of bacteria and inflammatory response, minimizes tissue inflammation, and relieves patient pain. Any excess modified starch not involved in hemostatic activity is readily dissolved and rinsed away through saline irrigation during operation. After treatment of surgical wounds, combat wounds, trauma and emergency wounds, the modified starch hemostatic material is rapidly absorbed by the body without the complications associated with gauze and bandage removal.

A modified starch material for biocompatible hemostasis, biocompatible adhesion prevention, tissue healing promotion, absorbable surgical wound sealing and tissue bonding, when applied as a biocompatible modified starch to the tissue of animals. The modified starch material produces hemostasis, reduces bleeding of the wound, extravasation of blood and tissue exudation, preserves the wound surface or the wound in relative wetness or dryness, inhibits the growth of bacteria and inflammatory response, minimizes tissue inflammation, and relieves patient pain. Any excess modified starch not involved in hemostatic activity is readily dissolved and rinsed away through saline irrigation during operation. After treatment of surgical wounds, combat wounds, trauma and emergency wounds, the modified starch hemostatic material is rapidly absorbed by the body without the complications associated with gauze and bandage removal.

The present invention aims to provide a method for producing a water-absorbing resin having excellent water absorption performance with high productivity. The present invention relates to a method for producing a water-absorbing resin that forms a physical gel upon absorption of water, the method including: (a1) reducing the molecular weight of a starch to obtain a partially degraded starch; (a2) introducing an acidic group into the partially degraded starch obtained in (a1) to obtain a water-soluble polymer; and (a3) drying the water-soluble polymer at 70 C. to 180 C. in the presence of water so that it has a solid content of 90% or more.

The present invention aims to provide a method for producing a water-absorbing resin having excellent water absorption performance with high productivity. The present invention relates to a method for producing a water-absorbing resin that forms a physical gel upon absorption of water, the method including: (a1) reducing the molecular weight of a starch to obtain a partially degraded starch; (a2) introducing an acidic group into the partially degraded starch obtained in (a1) to obtain a water-soluble polymer; and (a3) drying the water-soluble polymer at 70 C. to 180 C. in the presence of water so that it has a solid content of 90% or more.

The present disclosure relates to a method for preparing carboxyalkylated polysaccharides and a method for preparing a biodegradable super absorbent polymer using the same. More specifically, it relates to a method for preparing carboxyalkylated polysaccharides with high substitution efficiency by performing the carboxyalkylation reaction under high torque induced by gelatinization while using a specific content of water. In addition, it relates to a method for preparing a biodegradable super absorbent polymer capable of producing a super absorbent polymer with high water retention capacity by self-crosslinking the carboxyalkylated polysaccharide prepared therefrom.

The present disclosure relates to a method for preparing carboxyalkylated polysaccharides and a method for preparing a biodegradable super absorbent polymer using the same. More specifically, it relates to a method for preparing carboxyalkylated polysaccharides with high substitution efficiency by performing the carboxyalkylation reaction under high torque induced by gelatinization while using a specific content of water. In addition, it relates to a method for preparing a biodegradable super absorbent polymer capable of producing a super absorbent polymer with high water retention capacity by self-crosslinking the carboxyalkylated polysaccharide prepared therefrom.

Disclosed are a M-cell targeting and pH-responsive starch-based carrier material, and a preparation method and application thereof. The starch-based carrier material has a molecular structure as follows, a molecular weight of 7.0410.sup.4 to 2.1110.sup.6 g/mol, a degree of substitution of carboxymethyl groups of 0.04 to 0.28, and a grafting amount of targeting peptide GRGDS of 0.01% to 1.12% (calculated based on the content of N). The material is not dissolved in water when protonated at pH (pH=1.2) of the stomach, and is slowly dissolved in water when deprotonated at pH (pH=6.8) of the small intestine, therefore it has good responsiveness to pH of the gastrointestinal tract. The material can efficiently encapsulate a positively charged active substance by means of electrostatic interaction, therefore it can protect the active substances from being destroyed and inactivated in the gastrointestinal tract. Meanwhile, the material can target M cells to improve the transport efficiency of the active substance by M cells, thereby improving the bioavailability of the active substance.

A polymer composition may have excellent biodegradability and absorption capacity. The polymer composition may include a polysaccharide component. The polymer composition may have excellent biodegradability and absorption capacity by controlling the ratio of amylose in the polysaccharide component, the ratio of amylopectin in the polysaccharide component, and the molecular weight of the polysaccharide component.

The present application relates to a polymer material and a use thereof. The present application can provide a polymer material having both excellent biodegradability and absorptivity by using a polysaccharide component capable of efficient cross-linking while using no cross-linking agent that can adversely affect biodegradability, or using the relevant component to the minimum. The present application can also provide a use of the polymer material.