A zwitterionic monomer and corresponding cyclopolymerized polyzwitterion () (PZ) (i.e. poly(Z-alt-SO.sub.2). Phosophonate ester hydroloysis in PZ gave a pH-responsive polyzwitterionic acid () (PZA). The PZA under pH-induced transformation was converted into polyzwitterion/anion () (PZAN) and polyzwitterion/dianion (=) (PZDAN).

A zwitterionic monomer and corresponding cyclopolymerized polyzwitterion () (PZ) (i.e. poly(Z-alt-SO.sub.2). Phosophonate ester hydroloysis in PZ gave a pH-responsive polyzwitterionic acid () (PZA). The PZA under pH-induced transformation was converted into polyzwitterion/anion () (PZAN) and polyzwitterion/dianion (=) (PZDAN).

A zwitterionic monomer and corresponding cyclopolymerized polyzwitterion () (PZ) (i.e. poly(Z-alt-SO.sub.2). Phosophonate ester hydroloysis in PZ gave a pH-responsive polyzwitterionic acid () (PZA). The PZA under pH-induced transformation was converted into polyzwitterion/anion () (PZAN) and polyzwitterion/dianion (=) (PZDAN).

The disclosure provides polymers and compositions thereof, as well as methods for preparing such polymers and compositions. Also provided is a method of using the polymers or compositions thereof for binding uric acid or precursor thereof, and/or for treating hyperuricemia, gout, and/or diseases caused by hyperuricemia.

The disclosure provides polymers and compositions thereof, as well as methods for preparing such polymers and compositions. Also provided is a method of using the polymers or compositions thereof for binding uric acid or precursor thereof, and/or for treating hyperuricemia, gout, and/or diseases caused by hyperuricemia.