Embodiments of the present application relate to polymers used as polymeric polyvalent hub for liquid phase oligonucleotide synthesis. Methods for making an oligonucleotide by liquid phase oligonucleotide synthesis using the polyvalent hub are also provided.

The invention relates to a thickened preparation comprising a polymer which can be obtained by radical emulsion polymerization of at least one acidic vinyl monomer or salt thereof, at least one non-ionic vinyl monomer, in particular preferably a hydrophobic non-ionic vinyl monomer, at least one monomer containing an unsaturated terminal group and a polyoxyalkyene portion, at least one crosslinking monomer, optionally a protective colloid, and is characterized in that the polymerization is controlled such that the gelling effect occurs at least at times, which is achieved by the monomer addition (dosing time) taking place for 40 minutes, particularly preferably for 30 minutes.

The invention relates to a thickened preparation comprising a polymer which can be obtained by radical emulsion polymerization of at least one acidic vinyl monomer or salt thereof, at least one non-ionic vinyl monomer, in particular preferably a hydrophobic non-ionic vinyl monomer, at least one monomer containing an unsaturated terminal group and a polyoxyalkyene portion, at least one crosslinking monomer, optionally a protective colloid, and is characterized in that the polymerization is controlled such that the gelling effect occurs at least at times, which is achieved by the monomer addition (dosing time) taking place for 40 minutes, particularly preferably for 30 minutes.

The invention relates to a polymer which can be obtained by radical emulsion polymerization of at least one acidic vinyl monomer or salt thereof, at least one non-ionic vinyl monomer, in particular preferably a hydrophobic non-ionic vinyl monomer, at least one monomer containing an unsaturated terminal group and a polyoxyalkyene portion, at least one crosslinking monomer, optionally a protective colloid, and is characterized in that the polymerization is controlled such that the gelling effect occurs at least at times, which is achieved by the monomer addition (dosing time) taking place for 40 minutes, particularly preferably for 30 minutes.

The invention relates to a polymer which can be obtained by radical emulsion polymerization of at least one acidic vinyl monomer or salt thereof, at least one non-ionic vinyl monomer, in particular preferably a hydrophobic non-ionic vinyl monomer, at least one monomer containing an unsaturated terminal group and a polyoxyalkyene portion, at least one crosslinking monomer, optionally a protective colloid, and is characterized in that the polymerization is controlled such that the gelling effect occurs at least at times, which is achieved by the monomer addition (dosing time) taking place for 40 minutes, particularly preferably for 30 minutes.

A process for the preparation of optionally asymmetric acetal compounds includes reacting a compound containing a hydroxyl group with a vinylether compound in the presence of a zwitterionic catalyst including at least one basic nitrogen containing structural fragment and at least one sulfonic acid group in its structure, with the proviso that a molar ratio of the basic nitrogen to sulfonic acid is 1:1.

A process for the preparation of optionally asymmetric acetal compounds includes reacting a compound containing a hydroxyl group with a vinylether compound in the presence of a zwitterionic catalyst including at least one basic nitrogen containing structural fragment and at least one sulfonic acid group in its structure, with the proviso that a molar ratio of the basic nitrogen to sulfonic acid is 1:1.

Provided are a compound represented by General Formula (1), a curable resin composition containing the compound, a cured product formed of the curable resin composition, a diffractive optical element, and augmented reality glasses.

##STR00001##

In the formula, .sup.L represents an alkylene group or a group that, among one CH.sub.2 or two or more CH.sub.2's not adjacent to each other in an alkylene group, CH.sub.2 not adjacent to an S atom is substituted with S, Sp.sup.a and Sp.sup.b represent a divalent aromatic hydrocarbon group or a divalent group formed by a combination of a divalent aromatic hydrocarbon group and an alkylene group, Pol.sup.1 and Pol.sup.2 represent a (meth)acryloylthio group or a vinylthio group, and n1 and n2 are 0 or 1.

Provided are a compound represented by General Formula (1), a curable resin composition containing the compound, a cured product formed of the curable resin composition, a diffractive optical element, and augmented reality glasses.

##STR00001##

In the formula, .sup.L represents an alkylene group or a group that, among one CH.sub.2 or two or more CH.sub.2's not adjacent to each other in an alkylene group, CH.sub.2 not adjacent to an S atom is substituted with S, Sp.sup.a and Sp.sup.b represent a divalent aromatic hydrocarbon group or a divalent group formed by a combination of a divalent aromatic hydrocarbon group and an alkylene group, Pol.sup.1 and Pol.sup.2 represent a (meth)acryloylthio group or a vinylthio group, and n1 and n2 are 0 or 1.

Embodiments of the present application relate to polymers used as polymeric polyvalent hubs for liquid phase oligonucleotide synthesis. Methods for making an oligonucleotide by liquid phase oligonucleotide synthesis using the polymers are also provided.