The present invention provides a biodegradable drug delivery composition comprising: (i) a mixture of at least three different block copolymers, wherein each block copolymer is: (a) a biodegradable triblock copolymer having the formula: A.sub.v-B.sub.w-A.sub.x wherein A is a polyester and B is polyethylene glycol and v and x are the number of repeat units from 1 to 3,000 and w is the number of repeat units from 3 to 300 and v=x or v≠x; or (b) a biodegradable diblock copolymer having the formula: C.sub.y-A.sub.z wherein A is a polyester and C is an end-capped polyethylene glycol and y and z are the number of repeat units with y=2 to 250 and z=1 to 3,000; and wherein the mixture comprises at least one (a) and at least one (b); and the weight ratio between (a) and (b) is 1:19 to 5:1; and (ii) at least one pharmaceutically active ingredient.

The present invention provides a biodegradable drug delivery composition comprising: (i) a mixture of at least three different block copolymers, wherein each block copolymer is: (a) a biodegradable triblock copolymer having the formula: A.sub.v-B.sub.w-A.sub.x wherein A is a polyester and B is polyethylene glycol and v and x are the number of repeat units from 1 to 3,000 and w is the number of repeat units from 3 to 300 and v=x or v≠x; or (b) a biodegradable diblock copolymer having the formula: C.sub.y-A.sub.z wherein A is a polyester and C is an end-capped polyethylene glycol and y and z are the number of repeat units with y=2 to 250 and z=1 to 3,000; and wherein the mixture comprises at least one (a) and at least one (b); and the weight ratio between (a) and (b) is 1:19 to 5:1; and (ii) at least one pharmaceutically active ingredient.

The invention relates to a method for the preparation of a hyperbranched polyester mixture obtainable by reacting a hydroxyl group containing carboxylic acid (B) with at least one carboxylic acid group and at least two hydroxyl groups with a diol (C) having a molecular weight of more than 100 g/mol, optionally in the presence of at least one further reactant, wherein the at least one further reactant is a polyol (A) having at least three hydroxyl groups under a reaction condition allowing ester and ether formation; and reacting the mixture resulting from step (a) with a hydrophobic carboxylic acid (D) resulting in the hyperbranched polyester mixture. The invention further relates to said hyperbranched polyester mixture and the use as wax inhibitor, as pour point depressant, as lubricant or in lubricating oils.

The invention relates to a method for the preparation of a hyperbranched polyester mixture obtainable by reacting a hydroxyl group containing carboxylic acid (B) with at least one carboxylic acid group and at least two hydroxyl groups with a diol (C) having a molecular weight of more than 100 g/mol, optionally in the presence of at least one further reactant, wherein the at least one further reactant is a polyol (A) having at least three hydroxyl groups under a reaction condition allowing ester and ether formation; and reacting the mixture resulting from step (a) with a hydrophobic carboxylic acid (D) resulting in the hyperbranched polyester mixture. The invention further relates to said hyperbranched polyester mixture and the use as wax inhibitor, as pour point depressant, as lubricant or in lubricating oils.

A block copolymer contains at least a block (P1) and a block (P2). The block (P1) is obtained or obtainable by reaction of a triblock copolymer having the structure A-B-A′, where block B is selected from polyethers or polyesters and blocks A and A′ are identical or different, and at least one polymer (PM) selected from polyesters and polyethers. The block (P2) is selected from polyamides and polyesters. A process can be used for producing the inventive block copolymer, a shaped article can be made containing the inventive block copolymer, and the inventive block copolymer can be used for producing a shaped article.

The present invention relates to polymers, compositions thereof, and methods of producing polymers in general. Furthermore, the present invention relates to pharmaceutical compositions and uses of said polymers, compositions and pharmaceutical compositions. More particular, the present invention relates to polymers of jasmine lactone, where pendant groups of said polymers can readily be used for attaching functional moieties comprising active agents. Furthermore, the present invention relates to modified jasmine lactones that can readily be used in methods of producing polymers of the present invention. More particular, the invention relates to polymers from renewable monomers, which can be used in applications such as drug delivery and diagnosis, polymer-drug conjugates, medical devices, cosmetic products, polymers with marker unit, polymers usable as flame retardants, tissue engineering, coatings, paints, lubricants and biodegradable plastics.

The present invention concerns the use of PCL in preparing a block copolymer comprising at least one rigid block and at least one flexible block, for enhancing the sebum resistance of said block copolymer.

The present invention also provides a sebum-resistant block copolymer, characterized in that it comprises rigid blocks and flexible blocks comprising at least 50% by weight of PCL, based on the total weight of flexible blocks, which represents 100%; a process for synthesizing said copolymer; and also compositions and articles comprising a sebum-resistant copolymer of this kind.

This invention relates to the synthesis of multi-block bioresorbable polymers bearing hard and soft polymeric segments. The invention further relates to bioresorbable polymers for shape memory properties. The invention also relates to the use of such polymers as bone filler, vascular closure devices, hemostasis device, aneurysms, mastectomy devices and stent applications. The invention relates also to the use of such polymers for applications in fast degradation applications and 3D printing. The invention also relates to the use of such polymers as drug delivery platforms applications.

A method to prepare a polylactic acid-based polymer; the method comprises: —a mixing step, during which lactide monomers, at least one polymerization catalyst and natural origin reactants are mixed together; —a polymerization step, during which the mixture obtained from the previous mixing step is heated at a temperature ranging from 120 to 220° C. in inert atmosphere; and —a cooling step, during which a polymer mass obtained from said polymerization step is cooled down. The natural origin reactants are: (i) a first compound with general formula (I) wherein n ranges from 1 to 20 (ii) a second compound chosen among citric acid, malic acid and derivatives thereof with the carboxylic groups partially or completely in the form of ester or anhydride and with the hydroxyl groups partially or completely in the form of ester.

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The present invention relates to an amphiphilic block copolymer represented by formula I, a preparation method thereof, and a nanomicelle drug delivery system formed from the copolymer and a poorly soluble drug. The amphiphilic block copolymer includes a hydrophilic chain segment, a hydrophobic chain segment, and a linker for linking the hydrophilic chain segment to the hydrophobic chain segment. The linker contains an unsaturated structure, which can enhance the interaction between the poorly soluble drug and the copolymer to improve the drug loading ability and stability of the nanomicelle. The invention also relates to a nanomicelle drug-loading system, a preparation method thereof, and the use of the nanomicelle drug-loading system for preparing medicines for treating tumors, inflammation, diabetes, central nervous system diseases, cardiovascular diseases, and psychological disorders.

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