Free-standing non-fouling polymers and polymeric compositions, monomers and macromonomers for making the polymers and polymeric compositions, objects made from the polymers and polymeric compositions, and methods for making and using the polymers and polymeric compositions

Provided herein are branched poly(beta-amino esters) (PBAE) useful as vehicles for the delivery of therapeutic agents, such as nucleic acids. The disclosed polymers form stable compositions, and are suitable for the delivery of therapeutic agents via nebulization. Compositions of the disclosed polymers are capable of delivering therapeutic agents such as mRNA to lung epithelial cells.

Linear, comb, and star shaped non-ionic polyesters and copolyesters, polyesteramides, polyamides, and copolyamides may be synthesized from the condensation polymerization of polyacids containing alpha-hydroxy polyacids and diols and/or polyols, and amino-diols and/or amines using boric acid, boric anhydride, and boronic acids as catalysts. Depending on the polyol, polyamine, and amino alcohol component, the resulting compound may be hydrophilic or hydrophobic, but not water soluble or dispersible, enabling use in packaging films, fibers, and other molded articles. The compounds may be completely water soluble, water dispersible, and/or amphipathic, thus being useful in cosmetics, agricultural compositions, biomedical and pharmaceutical applications.

Provided herein are branched poly(beta-amino esters) (PBAE) useful as vehicles for the delivery of therapeutic agents, such as nucleic acids. The disclosed polymers form stable compositions, and are suitable for the delivery of therapeutic agents via nebulization. Compositions of the disclosed polymers are capable of delivering therapeutic agents such as mRNA to lung epithelial cells.

Polyethylene glycol (PEG)-b-poly(β-amino ester) (PBAE) co-polymers (PEG-PBAE) and blends of PEG-PBAEs and PBAEs and their use for delivering drugs, genes, and other pharmaceutical or therapeutic agents safely and effectively to different sites in the body and to different cells, such as cancer cells, are disclosed.

A liquid crystal polyester comprising a structural unit derived from 6-hydroxy-2-naphthoic acid, wherein in thermal extraction GC-MS analysis of the liquid crystal polyester under the following measuring conditions, the relative content of the following impurity component determined from the GC peak area in the total ion chromatogram using methyl 6-hydroxy-2-naphthoate as a standard sample is 50 ppm or less based on the mass of the liquid crystal polyester, and the impurity component has main peaks at m/z=228, 186, 171, and 143 in the MS spectrum chart and a retention time detected in the range of 11.5 to 12.5 min in the total ion chromatogram.

The present invention is directed to bioresorbable polymers to be used as bone and tissue adhesives. The present invention is also directed to the synthesis of bioresorbable polymeric molecules bearing adhesive moieties and the use of such compounds in methods to glue and stabilize fractured bones and damaged tissues. The present invention is also directed to the use of such compounds as adhesive sealants for applications in wound care. The present invention is also directed to the use of such compounds as biodegradable ink for applications in tissue engineering and 3D printing. The present invention also relates to the use of such compounds as drug delivery platforms.

The invention features adhesive devices for holding objects (e.g., bone fragments) fixed with respect to each other.

Described herein is a detergent composition including (A) at least one polymer including (a) a core that includes one to 3 moieties of general formula (I),

##STR00001## where Z are different or the same and are selected from the group consisting of C.sub.2-C.sub.12-alkylene and C.sub.3-C.sub.12-cycloalkylene A.sup.1 are different or the same and are: selected from the group consisting of C.sub.1-C.sub.12-alkylene, C.sub.6-arylene, and C.sub.3-C.sub.12-cycloalkylene, or based on citric acid, X.sup.1 is selected from the group consisting of hydrogen, methyl, ethyl, and combinations of at least two of the foregoing, n is in a range of 1 to 100; and (b) polyalkylene oxide chains.

The invention provides a class of polymeric materials being ABA tri-block or AB di-block, comprised of biodegradable segments and poly(propylene oxide) (PPO) segment and uses thereof.