The present invention relates to processes for the formation of pyridinedicarboxylic acid (PDCA), in particular, 2,4-pyridinedicarboxylic acid (2,4-PDCA) and 2,5-pyridinedicarboxylic acid (2,5-PDCA), and mono- and diester derivatives thereof, from 3,4-dihydroxybenzoic acid, via a biocatalytic reaction using, for example, a protocatechuate dioxygenase such as protocatechuate 4,5-dioxygenase or protocatechuate 2,3-dioxygenase, and a nitrogen source. The invention also relates to copolymers that comprise the pyridinedicarboxylic acid monomers and derivatives thereof, processes for the formation of the copolymers and uses for the copolymers.

Provided herein are methods and systems for producing a thermally stable polylactone polymer comprising chain terminating the polymer with an end-capping agent to prevent scission of the polymer. Also provided is a thermally stable polylactone polymer wherein the polymer has a first end and a second end, wherein at least one of said first and second ends terminate in an end-capping agent.

Poly(amine-co-ester) polymers, methods of forming active agent-load polyplexes and particles therefrom, and methods of using them for delivery of nucleic acid agents with optimal uptake have been developed. Examples demonstrate critical molecular weights in combination with exposed carboxylic and/or hydroxyl groups, and methods of making. Typically, the compositions are less toxic, more efficient at drug delivery, or a combination thereof compared to a control other transfection reagents. In some embodiments, the compositions are suitable for in vivo delivery, and can be administered systemically to a subject to treat a disease or condition.

Poly(amine-co-ester) polymers, methods of forming active agent-load polyplexes and particles therefrom, and methods of using them for delivery of nucleic acid agents with optimal uptake have been developed. Examples demonstrate critical molecular weights in combination with exposed carboxylic and/or hydroxyl groups, and methods of making. Typically, the compositions are less toxic, more efficient at drug delivery, or a combination thereof compared to a control other transfection reagents. In some embodiments, the compositions are suitable for in vivo delivery, and can be administered systemically to a subject to treat a disease or condition.

Techniques regarding the synthesis of one or more polymers through one or more ring-opening polymerizations conducted within a flow reactor and facilitated by one or more anionic catalysts are provided. For example, one or more embodiments can comprise a method, which can comprise polymerizing, via a ring-opening polymerization within a flow reactor, a cyclic monomer in the presence of one or more anionic organocatalysts.

Techniques regarding the synthesis of one or more polymers through one or more ring-opening polymerizations conducted within a flow reactor and facilitated by one or more anionic catalysts are provided. For example, one or more embodiments can comprise a method, which can comprise polymerizing, via a ring-opening polymerization within a flow reactor, a cyclic monomer in the presence of one or more anionic organocatalysts.

Embodiments of the present disclosure are directed towards solvent-based compositions that include a reaction product formed by reacting a polyol and an aminopolycarboxylic compound.

The chelation crosslinked polymers include a polymer backbone having one or more chelation crosslinking group(s) at least partially bonded to one or more cation(s). The chelation crosslinking groups may be within a polymer backbone and/or pendant from the polymer backbone. The chelation crosslinked polymers may be chelation crosslinked polyesters. The chelation crosslinked polymers can be used in tissue engineering applications to form tissue grafts and scaffolds.

Provided is a compound which may be obtained by esterification condensation of components as described herein. The compound may be used as a collector for ore enrichment (flotation), as a corrosion inhibitor, as a viscosity enhancer, emulsifier or stabilizer that is useful for the oil and gas industry, as a clay modifier, as an adhesion promoter, as an antiagglomerant additive, as an additive in haircare products, as a fabric softener, as an antistatic agent in polymers, as a bitumen emulsion additive, as a detergency cationic agent, as a fertilizer additive, as an antiagglomerant for hydrates, as a lubrication or adhesion-promoting additive, for example.

Provided is a triblock copolymer comprising a poly(3-hydroxypropionate) block, and polylactide blocks bonded to both ends of the poly(3-hydroxypropionate) block. Also provided is a method for preparing a triblock copolymer by ring-opening polymerization of lactide monomers in the presence of a poly(3-hydroxypropionate) initiator having hydroxy groups at both ends.