An anti-tumor nano adjuvant is obtained by loading a drug on the vesicle formed by a reversibly cross-linked biodegradable polymer with an asymmetric membrane structure; the drug is an oligonucleotide activating an immune response; the vesicle formed by the degradable polymer is obtained by the self-assembly of a polymer followed by cross-linking; the molecular chain of the polymer includes a hydrophilic chain segment, a hydrophobic chain segment and positively charged molecules, successively connected; the hydrophobic chain segment is a polycarbonate chain segment and/or a polyester chain segment, which is compounded and loaded with a drug by electrostatic interaction; and the membrane is a polycarbonate chain segment and/or a polyester chain segment, which is reversibly cross-linked, biodegradable and has good biocompatibility, the dithiolane in the side chain thereof is similar to thioctic acid, a natural antioxidant in human body, and the shell thereof is based on PEG and targets cancer cells.

The present invention is a composition of an agent for treating a precursor of a three-dimensional object for removing a support material from a precursor of the three-dimensional object containing a three-dimensional object and the support material, the composition containing water and a water-soluble compound having a solubility parameter (SP value) calculated by using the Fedors' method of 8 (cal/cm.sup.3).sup.1/2 to 13 (cal/cm.sup.3).sup.1/2. The present invention can provide a composition of an agent for treating a precursor of a three-dimensional object that is capable of removing the support material quickly and a method for manufacturing a three-dimensional object using the composition of an agent for treating a precursor of a three-dimensional object by a fused deposition modeling system.

Provided herein are biodegradable polymers and nanoparticles comprising such polymers. The present nanoparticles deliver antibiotics to infected tissue with enhanced antibacterial efficacy. Thus, the present technology provides a nanoparticle comprising: a surface comprising one or more polysaccharides having specific binding affinity for bacteria; a core comprising a biodegradable polymer; and an antibacterial drug loaded within the core; wherein the biodegradable polymer comprises nitrogen-containing ionizable functional groups; the one or more polysaccharides having specific binding affinity for bacteria; and disulfide groups; the one or more polysaccharides are attached to the biodegradable polymer through phenyl boronic ester linkages; and the nanoparticle surface displays the polysaccharides such that the polysaccharide are available to bind to a bacterial cell surface.

Provided herein are biodegradable polymers and nanoparticles comprising such polymers. The present nanoparticles deliver antibiotics to infected tissue with enhanced antibacterial efficacy. Thus, the present technology provides a nanoparticle comprising: a surface comprising one or more polysaccharides having specific binding affinity for bacteria; a core comprising a biodegradable polymer; and an antibacterial drug loaded within the core; wherein the biodegradable polymer comprises nitrogen-containing ionizable functional groups; the one or more polysaccharides having specific binding affinity for bacteria; and disulfide groups; the one or more polysaccharides are attached to the biodegradable polymer through phenyl boronic ester linkages; and the nanoparticle surface displays the polysaccharides such that the polysaccharide are available to bind to a bacterial cell surface.

A resin includes a unit represented by Chemical Formula 1, a method for preparing the same, a resin composition including the same, and a molded article including the resin composition

##STR00001## in Chemical Formula 1, Ar1, Ar2, R1, r1, X1 to X4, Z1, Z2, a and b are described herein.

A water dispersible sulfopolymer for use as a material in the layer-wise additive manufacture of a 3D part made of a non water dispersible polymer wherein the water dispersible polymer is a reaction product of a metal sulfo monomer, the water dispersible sulfo-polymer being dispersible in water resulting in separation of the water dispersible polymer from the 3D part made of the non water dispersible polymer.

A coating composition containing a polyester resin (A) having an acid value of not lower than 5 mgKOH/g, a polyester resin (B) having an acid value of lower than 5 mgKOH/g, and a curing agent having a functional group capable of crosslinking reaction with a carboxyl group. Assuming that the total solid content mass of the polyester resin (A) and the polyester resin (B) is 100 parts by mass, the content of the polyester resin (A) is in a range of more than 50 parts by mass to not more than 97 parts by mass, and the content of the polyester resin (B) is in a range of not less than 3 parts by mass to less than 50 parts by mass. Also disclosed is a coated metal substrate and a drawn-ironed can formed of the coated metal substrate.

Radical cascade reactions enabling sequence-controlled ring-closing polymerization and ring-opening polymerization for the controlled synthesis of polymers with complex main-chain structures are provided. Facile syntheses leading to low-strain macrocyclic monomers consisting of the ring-opening triggers and extended main-chain structures are also provided. The present disclosure further provides methods for excellent control over polymer molecular weights and molecular weight distributions and high chain-end fidelity allows for the preparation of polymeric systems with well-defined architectures. Further provided are the general nature of the radical cascade-triggered transformations in polymer chemistry, and its application to the synthesis of polymers with diverse main-chain structural motifs with tailored functions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

Radical cascade reactions enabling sequence-controlled ring-closing polymerization and ring-opening polymerization for the controlled synthesis of polymers with complex main-chain structures are provided. Facile syntheses leading to low-strain macrocyclic monomers consisting of the ring-opening triggers and extended main-chain structures are also provided. The present disclosure further provides methods for excellent control over polymer molecular weights and molecular weight distributions and high chain-end fidelity allows for the preparation of polymeric systems with well-defined architectures. Further provided are the general nature of the radical cascade-triggered transformations in polymer chemistry, and its application to the synthesis of polymers with diverse main-chain structural motifs with tailored functions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

A composition for forming a resist underlayer film that enables formation of an intended resist pattern, and a method for producing a resist pattern and a method for producing a semiconductor device, each of which uses said composition for forming a resist underlayer film. A composition for forming an EUV resist underlayer film includes: a compound represented by formula (1); a polymer; and an organic solvent. (In formula (1), Y1 represents a single bond, an oxygen atom, a sulfur atom, a halogen atom, or a C1-10 alkylene group which may be substituted with a C6-40 aryl group, or a sulfonyl group, T1 and T2 each represent a C1-10 alkyl group, R1 and R2 each independently represent a C1-10 alkyl group which is substituted with at least one hydroxy group, and n1 and n2 each independently represent an integer of 0-4).