The present invention relates to a process for producing a (co)polyester, wherein the (co)polyester at least partially consists of 1,4-butylene dicarboxylate units, in a degassing plant, wherein the crude (co)polyester is degassed in the presence of 0.1% to 5% by weight, based on the total weight of the input materials, of an entraining agent at a pressure between 5 to 300 mbar.

A method for preparing a biogenic guanidine complex, the method including: mixing dimethyl sulfoxide (DMSO) with water in a volume ratio thereof of 1:1 to yield a solvent DMSO-H.sub.2O; adding organic guanidine (G) and a compound MX.sub.2 in a molar ratio G/MX.sub.2=1:1 or 2:1 to the solvent DMSO-H.sub.2O, where the organic guanidine (G) is selected from arginine (Arg), guanidinoacetic acid (Gaa), creatine (Cra), creatinine (Cran), guanine (Gua), and agmatine (Agm); M represents Fe.sup.2+, Mg.sup.2+, or Zn.sup.2+; and X represents Cl.sup.−, CH.sub.3COO.sup.−, or CH.sub.3CH(OH)COO.sup.−; stirring the solvent DMSO-H.sub.2O containing the organic guanidine and the compound MX.sub.2; recycling the solvent DMSO-H.sub.2O through vacuum distillation and obtaining a solid; transferring the solid to a Buchner funnel, and washing the solid with deionized water and ethanol consecutively; and removing the deionized water and ethanol through vacuum filtration, and drying the solid.

A method for preparing a biogenic guanidine complex, the method including: mixing dimethyl sulfoxide (DMSO) with water in a volume ratio thereof of 1:1 to yield a solvent DMSO-H.sub.2O; adding organic guanidine (G) and a compound MX.sub.2 in a molar ratio G/MX.sub.2=1:1 or 2:1 to the solvent DMSO-H.sub.2O, where the organic guanidine (G) is selected from arginine (Arg), guanidinoacetic acid (Gaa), creatine (Cra), creatinine (Cran), guanine (Gua), and agmatine (Agm); M represents Fe.sup.2+, Mg.sup.2+, or Zn.sup.2+; and X represents Cl.sup.−, CH.sub.3COO.sup.−, or CH.sub.3CH(OH)COO.sup.−; stirring the solvent DMSO-H.sub.2O containing the organic guanidine and the compound MX.sub.2; recycling the solvent DMSO-H.sub.2O through vacuum distillation and obtaining a solid; transferring the solid to a Buchner funnel, and washing the solid with deionized water and ethanol consecutively; and removing the deionized water and ethanol through vacuum filtration, and drying the solid.

An object of the present invention is to provide a method for producing PHA capable of providing PHA (for example, a PHA powder) having excellent thermal stability with high productivity. The present invention is a method for producing polyhydroxyalkanoic acid, the method including a step (a) and a step (b) below: step (a) of preparing an aqueous suspension liquid containing polyhydroxyalkanoic acid and polyvinyl alcohol and having a pH of 7 or less; and step (b) of spray-drying the aqueous suspension liquid prepared in the step (a).

The present invention relates to a process for the manufacture of an epoxy-functional polyester, and to solid epoxy-functional polyesters made by such process and to a coating composition, in particular a powder coating composition, comprising such solid epoxy-functional polyester. The polyester made as disclosed herein is particularly useful in powder coatings.

The present invention relates to a process for the manufacture of an epoxy-functional polyester, and to solid epoxy-functional polyesters made by such process and to a coating composition, in particular a powder coating composition, comprising such solid epoxy-functional polyester. The polyester made as disclosed herein is particularly useful in powder coatings.

Provided a method for separating PHA and PHA prepared therefrom. The method comprises the following steps: subjecting a PHA fermentation broth to solid-liquid separation to obtain a thallus precipitate; breaking cell walls of the thallus precipitate, and subjecting obtained wall-broken products to a plate and frame filtration to obtain PHA; a filter cloth for the plate and frame filtration is pre-coated with a PHA layer. The method adopts a plate and frame separation to replace the traditional centrifugal separation to prepare PHA, and the PHA layer is pre-coated on the filter cloth for the plate and frame filtration, thereby overcome the defects in the prior art such as high cost and operational difficulty caused by adopting multiple centrifugal separations; in addition, the method of the present disclosure also exhibits the advantages of high recovery rate of PHA and high purity of the prepared PHA product.

Provided a method for separating PHA and PHA prepared therefrom. The method comprises the following steps: subjecting a PHA fermentation broth to solid-liquid separation to obtain a thallus precipitate; breaking cell walls of the thallus precipitate, and subjecting obtained wall-broken products to a plate and frame filtration to obtain PHA; a filter cloth for the plate and frame filtration is pre-coated with a PHA layer. The method adopts a plate and frame separation to replace the traditional centrifugal separation to prepare PHA, and the PHA layer is pre-coated on the filter cloth for the plate and frame filtration, thereby overcome the defects in the prior art such as high cost and operational difficulty caused by adopting multiple centrifugal separations; in addition, the method of the present disclosure also exhibits the advantages of high recovery rate of PHA and high purity of the prepared PHA product.

A PLG copolymer material, termed a PLG(p) copolymer material, adapted for use in a controlled release formulation for a bioactive material is provided, wherein the formulation exhibits a reduced “initial burst” effect when introduced into the tissue of a patient in need thereof. A method of preparation of the PLG copolymer material is also provided, as are methods of use.

A PLG copolymer material, termed a PLG(p) copolymer material, adapted for use in a controlled release formulation for a bioactive material is provided, wherein the formulation exhibits a reduced “initial burst” effect when introduced into the tissue of a patient in need thereof. A method of preparation of the PLG copolymer material is also provided, as are methods of use.