The disclosure provides a capture system and methods for isolating cysteine-containing peptides from biological fluid and proteolytic mixtures. The disclosure also provides compounds of formulae (II), (III), and (IV), useful in methods of the invention. ##STR00001##

Pre-polymers for use as tissue sealants and adhesives, and methods of making and using thereof are provided. The pre-polymers have flow characteristics such that they can be applied through a syringe or catheter but are sufficiently viscous to remain in place at the site of application and not run off the tissue. The pre-polymers are also sufficiently hydrophobic to resist washout by bodily fluids. The pre-polymers are stable in bodily fluids; that is the pre-polymer does not spontaneously crosslink in bodily fluids absent the presence of an intentionally applied stimulus to initiate crosslinking. Upon crosslinking, the adhesive exhibits significant adhesive strength in the presence of blood and other bodily fluids. The adhesive is sufficiently elastic that it is able to resist movement of the underlying tissue. The adhesive can provide a hemostatic seal. The adhesive is biodegradable and biocompatible, causing minimal inflammatory response.

An electrophotographic developer set comprising a toner, and a powder adhesive, wherein the powder adhesive comprises a crystalline polyester resin, and a thermoplastic resin other than the crystalline polyester resin; the amount of the crystalline polyester resin in the powder adhesive is 21% by mass or more; the melting point of the crystalline polyester resin is 55° C. to 100° C.; in a viscoelasticity measurement, where Gt′(100) denotes a storage elastic modulus of the toner at 100° C. and Gb′(100) denotes a storage elastic modulus of the powder adhesive at 100° C., Gb′(100) is 1.0×10.sup.5 Pa or less and Gt′(100)/Gb′(100) is 1.2 or more.

The present invention relates to a process for the manufacture of an epoxy-functional polyester, and to solid epoxy-functional polyesters made by such process and to a coating composition, in particular a powder coating composition, comprising such solid epoxy-functional polyester. The polyester made as disclosed herein is particularly useful in powder coatings.

This invention relates to a curable coating composition comprising: I. at least one acetoacetate functional polyester further comprising the residues of a. a hydroxyl component comprising: i. a diol in an amount ranging from 70 to 100 mole %, based on the total moles of (i) and (ii); and ii. a polyol in an amount ranging from 0 to 30 mole %, based on the total moles of (i) and (ii); b. a carboxyl component comprising a polycarboxylic acid compound, a derivative of polycarboxylic acid compound, or a combination thereof; and c. an alkyl acetoacetate, a diketene, or a combination thereof in an amount ranging from about 5 to about 50 weight %, based on the total weight of (a), (b), and (c). II. a curing agent having two or more aldehyde functional groups, and III. a basic catalyst.

The method is described herein for forming a polymer, comprising providing a first monomer comprising a polyol having at least two hydroxyl groups; providing a second monomer comprising a polyalkyl ester of a polycarboxylic acid having at least two alkyl ester groups; mixing the first monomer and the second monomer to form a reaction mixture; and reacting the first monomer and the second monomer in the mixture by transesterification to form a polyester polymer, which may, if desired be crosslinked. The polymers may also be copolymerized with other monomers. Polymers and copolymers formed from the method herein, as well as articles formed therefrom are also described. Such polymers and articles may be biocompatible and/or bioresorbable.

A pH-modulating poly(glycerol sebacate) composition includes poly(glycerol sebacate) and at least one pH-modulating agent associated with the poly(glycerol sebacate). A process of making a pH-modulating poly(glycerol sebacate) composition includes forming a poly(glycerol sebacate) by a water-mediated reaction from glycerol and sebacic acid and associating at least one pH-modulating agent with the poly(glycerol sebacate). A process of modulating a pH of a buffered aqueous solution includes placing a pH-modulating poly(glycerol sebacate) composition in a buffered aqueous solution. The pH-modulating agent is released into the buffered aqueous solution during degradation of the poly(glycerol sebacate) to reduce a decrease in pH of the buffered aqueous solution caused by degradation of the poly(glycerol sebacate).

A novel polymer is provided by polymerization of xylitol and dodecanedioic acid. The polymer, poly(xylitol-dodecanedioic acid) or PXDDA, shows high elasticity. PXDDA significantly improves cell adhesion and promotes cell proliferation compared to an FDA-approved polymer, poly(lactic acid), and tissue-culture plates. PXDDA can be synthesized by a simple melt condensation polymerization without the use of any toxic catalysts.

The present invention relates to a binder resin composition capable of giving a toner remarkably excellent in fusing property on polypropylene films, and to a toner for developing electrostatic images that contains the binder resin composition. [1] A binder resin composition for toners, containing an amorphous polyester resin which has a polyester resin-derived constituent moiety that is a constituent moiety derived from a polyester resin and a modified polypropylene polymer A-derived constituent moiety that is a constituent moiety derived from a modified polypropylene polymer A having a carboxylic acid group or a carboxylic anhydride group and in which the polyester resin-derived constituent moiety and the modified polypropylene polymer A-derived constituent moiety bond to each other via a covalent bond, wherein the polymer A is a polypropylene polymer terminally-modified with an unsaturated bond-having carboxylic acid compound or an anhydride thereof, and in the polyester resin, the amount of the polymer A-derived constituent unit is 8 parts by mass or more and 30 parts by mass or less relative to 100 parts by mass of the total of the alcohol component and the carboxylic acid component constituting the polyester resin-derived constituent moiety; and [2] a toner for developing electrostatic images, containing the binder resin composition of [1].

Resin particles each include a binder resin. The binder resin includes an amorphous polyester resin and a crystalline resin. The amorphous polyester resin includes alcohol monomers as one of constituent components. The alcohol monomers include propylene glycol. Abundance of the crystalline resin in a region from an outermost surface of each of the resin particles to a depth of 150 nm from the outermost surface is 4% or less relative to an amount of the crystalline resin in an entire region of each of the resin particles. A radiocarbon .sup.14C content of the resin particles is 5.4 pMC or greater.