The present disclosure is directed to certain polyethers copolymers, and polyether derivatives thereof, and methods of making and using the same. For example, the starting materials may include such species as citronellol, geraniol, dihydromyrcene, adipic acid, propanediol, ethylene glycol, glycerol, 1,9-nonanediol, and 1,6-hexanediol.

The present invention provides a production method for pseudo-polyrotaxane or polyrotaxane in which the degree of ring-shaped molecules included on straight-chain molecules, that is, the inclusion rate, has been controlled to be low and stable. The present invention provides a production method for polyrotaxane formed by blocking groups being positioned at both ends of a pseudo-polyrotaxane so ring-shaped molecules are not released, said pseudo-polyrotaxane being formed by ring-shaped molecules skewered through openings thereof by straight-chain molecules, wherein polyrotaxane is obtained by means of said method having: (A) a step for preparing straight-chain molecules which have acidic or basic functional groups on both ends; (B) a step for forming pseudo-polyrotaxane by means of having a step for mixing the straight-chain molecules, the ring-shaped molecules, and a first basic group or an acid addition salt (the acid addition salt is used when the straight-chain molecules have the acidic functional groups; a base addition salt is used when the straight-chain molecules have the basic functional groups); and (C) a step for providing blocking groups on both ends of the straight-chain molecules by means of having a step for mixing the obtained pseudo-polyrotaxane and a blocking group precursor.

Processes of preparing defined monomer sequence polymers are disclosed, in which a backbone portion of the polymer is first prepared by performing one or more sequential monomeric coupling reactions with intervening membrane diafiltration purification/isolation steps, followed by a step of decorating the backbone portion with one or more side chains at predetermined positions along its length. The process represents an improvement on prior art techniques, which impose limitations on the size of the side chains that may be present. Defined monomer sequence polymers that are obtainable by the processes are also disclosed.

Processes of preparing defined monomer sequence polymers are disclosed, in which a backbone portion of the polymer is first prepared by performing one or more sequential monomeric coupling reactions with intervening membrane diafiltration purification/isolation steps, followed by a step of decorating the backbone portion with one or more side chains at predetermined positions along its length. The process represents an improvement on prior art techniques, which impose limitations on the size of the side chains that may be present. Defined monomer sequence polymers that are obtainable by the processes are also disclosed.

A fluorinated aromatic sulfone polymer [polymer (F-PS)] comprising: recurring units [units (A)] derived from at least one dihalo-diaryl sulfone [monomer (A)]; recurring units [units (B)] derived from at least one aromatic diol [monomer (B)]; at least one unit [units (PFPE)] derived from at least one fully or partially fluorinated polyether alcohol (PFPE alcohol), said polymer (F-PS) having a fluorine content ranging from 0.1% to 10% wt, is herein disclosed. Films and membranes obtained from (F-PS) are also disclosed, as well as their use in filtration methods.

The invention encompasses hydrogels, monomer precursors of the hydrogels, methods for the preparation thereof, and methods of use therefor. The linking of monomers can take place using non-radical, bioorthogonal reactions such as copper-free click-chemistry.

The invention encompasses hydrogels, monomer precursors of the hydrogels, methods for the preparation thereof, and methods of use therefor. The linking of monomers can take place using non-radical, bioorthogonal reactions such as copper-free click-chemistry.

A temozolomide compound according to formula (I)

##STR00001##

is described, wherein R.sup.1, L.sup.1, and X are defined herein. The temozolomide compound can be used to prepare polymers comprising temozolomide. Additionally, the polymers comprising temozolomide can be particularly useful in the treatment of certain diseases.

A temozolomide compound according to formula (I)

##STR00001##

is described, wherein R.sup.1, L.sup.1, and X are defined herein. The temozolomide compound can be used to prepare polymers comprising temozolomide. Additionally, the polymers comprising temozolomide can be particularly useful in the treatment of certain diseases.

According to one aspect of the present invention, an organic fluorine compound is represented by a general formula

(R--E-CH.sub.2).sub.2-A(1A)

(where A is a divalent perfluoropolyether group, is an arylene group or a single bond, R is an alkenyl group or an alkynyl group, and E is an ether bond or an ester bond or a group that is represented by a chemical formula

OCH.sub.2CH(OH)CH.sub.2O

two groups each of which is represented by a general formula

R--E-CH.sub.2

may be the same or different, and at least one n among two is an arylene group).