A temozolomide compound according to formula (I)

##STR00001##

is described, wherein R.sup.1, L.sup.1, and X are defined herein. The temozolomide compound can be used to prepare polymers comprising temozolomide. Additionally, the polymers comprising temozolomide can be particularly useful in the treatment of certain diseases.

Disclosed herein are linker units comprising a center core, a plurality of linking arms, and optionally, a coupling arm. According to the embodiments of the present disclosure, the present linker units further comprises a targeting element and an effector element. Also disclosed herein are methods for treating various diseases using such linker units.

The present invention provides four-branched water-soluble polymers for medical use that are represented by the following formula (1) or the formula (2) (the symbols in the following formulas are as defined in the specification.

##STR00001##

The present invention provides four-branched water-soluble polymers for medical use that are represented by the following formula (1) or the formula (2) (the symbols in the following formulas are as defined in the specification.

##STR00001##

A coating composition, a method for coating a substrate and a pipeline are provided. The coating composition includes at least one epoxy resin and at least one functionalized elastomer. The functionalized elastomer includes an elastomer being grafted with acid anhydride-based groups. The method includes steps of applying the coating composition to the substrate, and curing the coating composition so as to obtain a coating. The pipeline includes a pipe and the coating formed from the coating composition coated on the pipe. The coating has improved flexibility, and improved heat and chemical resistance.

Methods, compounds, and compositions described herein generally relate to hemiaminal organogel networks (HDCNs) and methods of forming HDCNs. In some embodiments, a hemiaminal organogel has a plurality of first polymers, each having a first end and a second end, a plurality of second polymers, each having a first end and a second end, and a plurality of trivalent aminal-hemiaminal linkages. The first end of each polymer of the plurality of first polymers may be covalently bonded to a first trivalent aminal-hemiaminal linkage. The second end of each polymer of the plurality of first polymers may be covalently bonded to a second trivalent aminal-hemiaminal linkage. The first end of each polymer of the plurality of second polymers may be covalently bonded to one of the plurality of trivalent aminal-hemiaminal linkages. The second end of each polymer of the plurality of second polymers may be non-covalently bonded.

The present invention relates to the use of at least one tetra functional non-ionic amphiphilic block copolymer as a vehicle for capped or uncapped mRNA for intracellular delivery for gene therapy.

The present invention relates to hydrophilic, i.e., water loving coatings (hereafter referred to as WLC). Polyurethane epoxy alkylene oxide coatings usable as coatings on for example, medical devices are a preferred WLC.

The present invention relates to new formulations for adhesive compositions and also to adhesive compositions particularly for a hybrid adhesive comprising at least one mixture of an amino resin and at least one polyether, and the combination of this mixture with isocyanate, and also to the use of polyethers in adhesives based on amino resins. These adhesive compositions are especially suitable for use as adhesives for woodbase materials, more particularly OSB boards, fiberboards, or chipboards. In a further aspect the present invention relates to processes for producing such woodbase materials from lignocellulosic products of comminution, more particularly to processes for producing OSB boards, wood fiberboards, or chipboards, where the lignocellulosic products of comminution are contacted with the adhesive composition of the invention and subsequently the woodbase materials are obtained by pressing with heat treatment. Lastly, the present invention is directed to woodbase materials obtainable accordingly.

Through an optical material composition containing a compound (a), a compound (b), a polythiol (c) and sulfur (d) according to the present invention, good mold release properties are obtained, and the occurrence of separation mark defects can be suppressed. Compound (a): a compound having the structure represented by formula (1): ##STR00001## (In formula (1), m is an integer of 0 to 4 and n is an integer of 0 to 2.) Compound (b): a compound having the structure represented by formula (2): ##STR00002## (In formula (2), m is an integer of 0 to 4 and n is an integer of 0 to 2.)