Provided are polyphosphazenes and methods of making and using the polyphosphazenes. The polyphosphazenes can be essentially chloride free. The polyphosphazenes can be phosphazene polyacids. The polyphosphazenes can be used as surface coatings, or as adjuvants when combined with antigens.

Provided are polyphosphazenes and methods of making and using the polyphosphazenes. The polyphosphazenes can be essentially chloride free. The polyphosphazenes can be phosphazene polyacids. The polyphosphazenes can be used as surface coatings, or as adjuvants when combined with antigens.

Polyphosphazene polymers having immunomodulating activity, and the biomedical use of such polyphosphazene polymers, in conjunction with an antigen or an immunogen are disclosed.

Infrared-transparent and damage-resistant polymer optics with LWIR and/or MWIR transparency are provided. Some variations provide an optic containing at least 50 wt % of an infrared-transparent polymer, wherein the infrared-transparent polymer has a carbon-free polymer backbone, wherein the optic is characterized by at least 80% average transmission of radiation over a wavenumber band with cumulative wavenumber width of at least 1000 cm.sup.−1 contained within wavelengths from 3.1 μm to 5 μm and/or from 8.1 μm to 12 μm, and wherein the average transmission is defined as the percentage ratio of radiation intensity through an optic thickness of 25 microns divided by incident radiation intensity. Many polymer compositions and pendant groups are disclosed for use in the polymer optics.

Infrared-transparent and damage-resistant polymer optics with LWIR and/or MWIR transparency are provided. Some variations provide an optic containing at least 50 wt % of an infrared-transparent polymer, wherein the infrared-transparent polymer has a carbon-free polymer backbone, wherein the optic is characterized by at least 80% average transmission of radiation over a wavenumber band with cumulative wavenumber width of at least 1000 cm.sup.−1 contained within wavelengths from 3.1 μm to 5 μm and/or from 8.1 μm to 12 μm, and wherein the average transmission is defined as the percentage ratio of radiation intensity through an optic thickness of 25 microns divided by incident radiation intensity. Many polymer compositions and pendant groups are disclosed for use in the polymer optics.

The present invention provides a hydrogel for comprising a biodegradable polyphosphazene polymer, a radiation-sensitive diselenide cross-linker; and one or more payloads releasably loaded within the hydrogel. The present invention further provides methods for radiosensitizing target tissues such as tumors and providing sustained delivery of therapeutics triggered by irradiation. In another aspect, the present invention provides a method that includes: introducing the hydrogel, as describes herein, adjacent to malignant or marginal tissue; and administering radiation to the hydrogel, thereby disrupting the selenocystamine cross-linkers and releasing the one or more payloads.

The present invention provides a hydrogel for comprising a biodegradable polyphosphazene polymer, a radiation-sensitive diselenide cross-linker; and one or more payloads releasably loaded within the hydrogel. The present invention further provides methods for radiosensitizing target tissues such as tumors and providing sustained delivery of therapeutics triggered by irradiation. In another aspect, the present invention provides a method that includes: introducing the hydrogel, as describes herein, adjacent to malignant or marginal tissue; and administering radiation to the hydrogel, thereby disrupting the selenocystamine cross-linkers and releasing the one or more payloads.

The present invention relates to a new class of cationic linear polyphosphazenes bearing as side groups a hydrophilic poly(ethylene glycol) and a spacer group selected from the group consisting of lysine, oligopeptides containing lysine, amino-ethanol, amino-propanol, amino-butanol, amino-pentanol and amino-hexanol, and the polyphosphazene-drug conjugates comprising hydrophobic anticancer drugs by covalent bonding and the preparation methods thereof. The present polyphosphazene-drug conjugates exhibit outstanding tumor selectivity and low toxicity.

The present invention relates to a new class of cationic linear polyphosphazenes bearing as side groups a hydrophilic poly(ethylene glycol) and a spacer group selected from the group consisting of lysine, oligopeptides containing lysine, amino-ethanol, amino-propanol, amino-butanol, amino-pentanol and amino-hexanol, and the polyphosphazene-drug conjugates comprising hydrophobic anticancer drugs by covalent bonding and the preparation methods thereof. The present polyphosphazene-drug conjugates exhibit outstanding tumor selectivity and low toxicity.

The disclosed invention relates to a composition comprising a crosslinked blend of polyphosphazene polymers. The composition comprises a first polyphosphazene and a second polyphosphazene, where the first polyphosphazene and the second polyphosphazene being bound by a thiol bearing crosslinking agent. Such compositions are useful as a membrane material for the separation of gasses in a gaseous mixture.