A fabrication method and application of topological elastomers with highly branched structures, low modulus and high elasticity. The topological elastomers comprise dendritic macromolecules. The fabrication method includes direct crosslinking, post-crosslinking, grafting, and copolymerization. The performance of the elastomer can be easily tuned via changing the topology of the polymer network. The breakthrough of this invention lies in that these topological elastomers with highly branched structures are having low modulus and high elasticity, which would expand its application in the field of elastomer. Notably, the variety of topological elastomers, the versatility of curing chemistries, the availability of a wide variety of monomers, and the various polymerization methods are enabling the fabrication of topological elastomers with feasibility and efficiency.

Methods for processing polynucleotide-containing biological samples, and materials for capturing polynucleotide molecules such as RNA and/or DNA from such samples. The RNA and/or DNA is captured by polyamindoamine (PAMAM (Generation 0)) bound to a surface, such as the surface of magnetic particles. The methods and materials have high efficiency of binding RNA and of DNA, and of release, and thereby permit quantitative determinations.

A method for producing a plated part, includes: forming, on a surface of a base member, a catalyst activity inhibiting layer containing a polymer which has at least one of an amide group and an amino group; irradiating with light or heating a part of the surface of the base member on which the catalyst activity inhibiting layer is formed; applying an electroless plating catalyst to the surface of the base member heated or irradiated with the light; and bringing an electroless plating solution into contact with the surface of the base member to which the electroless plating catalyst is applied, to form an electroless plating film at a light-irradiated portion or a heated portion of the surface.

A hydrogel comprising a particle physically entrapped within a hydrogel matrix, a method for making the hydrogel, a particle for use in the hydrogel and the use of the hydrogel to sense a chemical species, especially anions in solution. The particle comprises an active material and a plurality of chains of a first polymeric material, each of the chains of the first polymeric material having a first end and a second end. The active material and the first ends of the chains form a core; and the second ends of the chains extend outwardly away from the core to form a shell. The hydrogel matrix comprises chains of a second polymeric material in the form of a three dimensional cross-linked network.

The disclosure pertains to the field of treatment of patients with implantable delivery devices for long-term release of therapeutic agents. In particular, the disclosure provides devices and methods for the stabilization of the therapeutic agents inside the device for the duration of the implantation. The devices control the long-term release of the therapeutic agents by using a nanoporous membrane. The stabilization is achieved by using high-molecular weight stabilizers of a size that is larger than the diameter of the pores of the membrane, thereby preventing the release of the stabilizers.

The invention provides novel sugar alcohol-based dendrimer-like molecules. These sugar alcohol-based molecules have multiple functional groups that can be used to label, conjugate, and immobilize large amounts of molecules or multiple types of molecules of interest for diagnostic, therapeutic, and research usage. Methods of synthesizing these sugar alcohol-based dendrimer-like molecules and conjugates are also within the scope of the invention.

Provided herein are dendrimers comprising: a core unit, five generations of building units which are lysine residues or analogues thereof, first terminal groups comprising a cabazitazel residue covalently attached to a diglycolyl linker group, and second terminal groups comprising a PEG group. Also provided herein are pharmaceutical compositions comprising the dendrimers, and methods and uses of the dendrimers in therapy of disorders such as cancers. Processes for making the dendrimers and intermediates are also provided.

Chain scission resist compositions suitable for EUV lithography applications may include monomer functional groups that improve the kinetics and/or thermodynamics of the scission mechanism. Chain scission resists may include monomer functional groups that reduce the risk that leaving groups generated through the scission mechanism may chemically corrode processing equipment.

A distributed feedback laser having a conjugated dendrimer as the active lasing component, and a method for patterning conjugated dendrimers.

The present invention provides compositions of a therapeutic agent and a polymeric stabilizing agent for stabilizing the reservoir of an implantable drug delivery system. The present invention also includes an implantable drug delivery system incorporating the composition of the present invention, as well as methods of treating diabetes using the compositions and implantable drug delivery system of the present invention.