This disclosure provides improved lipid-based compositions, including lipid nanoparticle compositions, and methods of use thereof for delivering agents in vivo including nucleic acids and proteins. These compositions are not subject to accelerated blood clearance and they have an improved toxicity profile in vivo.

A responsive hydrogel-based material may be used as a carrier system for the in situ delivery of various cargo substances, including bioactive moieties. The hydrogel structure, which includes photodegradable and thioether moieties in its three dimensional network, enables finely tuned local release of cargo substances as a function of the in vivo tissue environment (e.g., enzyme concentration or reducing environment) and externally applied stimuli (e.g., light) by selective spatiotemporal hydrogel degradation.

Provided is a thermoplastic resin composition which has excellent heat resistance, mechanical characteristics, and adhesion properties with respect to a reinforcing fiber base material, which is a different kind of material, and from which a molded article particularly having excellent rigidity at a high temperature is obtained. A thermoplastic resin composition is provided, which includes: a phenoxy resin (A) having a hydroxy group and/or an epoxy group at a polymer chain terminal; and a polyamide resin (B), wherein a proportion of the phenoxy resin (A) is 50 to 90 mass % and a proportion of the polyamide resin (B) is 10 to 50 mass % relative to a total amount of 100 mass % of the phenoxy resin (A) and the polyamide resin (B), and a tensile modulus retention rate [Equation (i) below] of a dumbbell test piece (JIS K 7139, Type A1), and a molded article manufactured therefrom is also provided.

The invention provides for novel thermo-responsive polymers and compositions comprising the same. In some embodiments, the polymers are water soluble, pH-degradable and have tunable lower critical solution temperatures. Other aspects of the invention include micelles and gels comprising the thermo-responsive polymers and derivatives thereof, as well as methods of delivering therapeutic agents comprising administering a biodegradable gel or micelle comprising a polyacetal compound cross-linked with a linker.

Described herein are PEKK polymers having improved processability and improved crystallinity. It was surprisingly found that PEKK polymers formed using a specifically adapted nucleophilic synthesis route, in which different monomers are added in to the polymerization reaction at different points during the synthesis, had lower glass transition temperatures (“Tg”) and increased crystallinities, relative to PEKK polymers formed using traditional nucleophilic synthesis routes (“traditional PEKK polymers”). Furthermore, compared with PEKK polymers synthesized using an electrophilic synthesis routes, the PEKK polymers described herein and significantly lower halogen content. The synthesis routes includes a first heating of a first monomer blend in a reaction mixture, a subsequent first addition of a second monomer blend to the reaction mixture, and a second heating of the reaction mixture subsequent to the first addition.

To provide a hydrophilic polymer derivative having a novel linker technique which is able to from a hydrophilic polymer pro-drug of a drug containing an amino group or the like in order to overcome the restrictions of conventional hydrophilic polymer pro-drugs. A hydrophilic polymer derivative containing a hydrophilic polymer moiety and an acetal moiety, wherein the hydrophilic polymer derivative contains a structure represented by formula (1) or formula (2): ##STR00001##

The present invention relates to the use of at least one tetra functional non-ionic amphiphilic block copolymer as a vehicle for capped or uncapped mRNA for intracellular delivery for gene therapy.

Thermally-conductive gap fillers are described. The gap fillers comprise an aziridino-functional polyether polymer and thermally conductive particles. Initiators suitable for such systems ae also described. Such gap fillers may be used in various applications including the manufacture of battery modules and subunits.

A polyphenylene ether bismaleimide resin, a method for manufacturing the same, and a resin composition are provided. The polyphenylene ether bismaleimide (PPE-BMI) resin is obtained by a condensation reaction with a maleic anhydride and a primary amine compound as reactants. The primary amine compound is a polyphenylene ether diamine.

The invention provides a process for preparing a mixture (M) which comprises silane-terminated polymers (SP1) of the general formula (I)

Y.sup.1—[O—C(═O)—NH—(CR.sup.1.sub.2).sub.b—SiR.sub.a(OR.sup.2).sub.3-a].sub.x  (I),

optionally silane-terminated polymers (SP2) of the general formula (II)

Y.sup.2—[O—C(═O)—NH—(CR.sup.1.sub.2).sub.b—SiR.sub.a(OR.sup.2).sub.3-a].sub.z  (II) and hydroxy-functional polymers (SP3) of the general formula (III)

Y.sup.2—[O—C(═O)—NH—(CR.sup.1.sub.2).sub.b—SiR.sub.a(OR.sup.2).sub.3-a].sub.z-z1(OH).sub.z1  (III) where Y.sup.1 and Y.sup.2 are polymer radicals and R, R.sup.1, R.sup.2, x, z, z1, a and b have the definitions indicated in claim 1, wherein, in a first process step, at least one polymer (HP1) of the general formula (IV)

Y.sup.1—[OH].sub.x  (IV) reacts with at least one isocyanate-functional silane (S) of the general formula (V)

O═C═N—(CR.sup.1.sub.2).sub.b—SiR.sub.a(OR.sup.2).sub.3-a  (V) to give silane-terminated polymers (SP1), and, in a second process step, the unreacted isocyanate groups of the isocyanate-functional silane (S) of the general formula (V) are reacted with at least one oligomer or polymer (HP2) of the general formula (VI)

Y.sup.2(OH).sub.z  (VI); polymer mixtures (M) preparable by the process; and use of the polymer mixtures (M) for producing adhesives and sealants and also coatings.