A method of producing a medical polyoxypropylene polymer and a polyoxypropylene/polyoxyethylene block copolymer including (A) adding to a polyoxypropylene polymer which is obtained by ring-opening polymerization of propylene oxide to a starting substance having an active hydrogen reacting with the propylene oxide and contains allyl ether as an impurity, a tertiary alkoxide of alkali metal in an excess amount based on a molar number of the active hydrogen of the starting substance and heat treating at 115° C. or less to isomerize the allyl ether to propenyl ether; and (B) adding a mineral acid to the product obtained in step (A) to adjust pH to 4 or less and treating at 70° C. or less to hydrolyze the propenyl ether. Also disclosed is a method of producing a medical polyoxypropylene/polyoxyethylene block copolymer which includes performing ring-opening polymerization of ethylene oxide to the polyoxypropylene polymer obtained above.

The present invention relates to an agrochemical aqueous suspension concentrate comprising a pesticide in the form of pesticide particles and at least 5 wt % of an adjuvant dissolved in the aqueous phase, wherein the adjuvant is of the formula (I) as defined herein. The invention also relates to the adjuvant as defined in formula (I). Furthermore, the invention relates to a process for the preparation of the suspension concentrate by contacting water, the pesticide, and the adjuvant. The present invention further relates to a method of controlling phytopathogenic fungi and/or undesired plant growth and/or undesired insect or mite attack and/or for regulating the growth of plants.

Embodiments herein relate to compositions of and methods for live viruses. In certain embodiments, a live, attenuated virus composition includes, but is not limited to, one or more live, attenuated viruses and compositions to reduce inactivation and/or degradation of the live, attenuated virus. In other embodiments, the live, attenuated virus composition may be a vaccine composition. In yet other compositions, a live, attenuated virus composition may include at least one carbohydrate, at least one protein and at least one high molecular weight surfactants for reducing inactivation and/or degradation of the live, attenuated virus.

The invention relates to a process for producing a polyoxyalkylene polyol, comprising depositing an alkylene oxide onto an H-functional starter substance in the presence of a double metal cyanide (DMC) catalyst, wherein the alkylene oxide is dosed at the mass flow rate m(alkylene oxide), the H-functional starter substance is dosed at the mass flow rate m(starter substance), and the double metal cyanide (DMC) catalyst is dosed in a dispersant at the mass flow rate m(DMC) continuously into the reactor with the reaction volume V during the reaction, and the resulting reaction mixture is continuously removed from the reactor, and wherein the quotient of the sum of the mass flow rates Σ{dot over (m)} of {dot over (m)}(alkylene oxide), {dot over (m)}(starter substance) and {dot over (m)}(DMC) to give the reaction volume V in the steady state is greater than or equal to 1200 g/(h.Math.L).

The vinylidene-fluoride-based polymer composition according to the present invention comprises a vinylidene-fluoride-based polymer and a specific surfactant and contains no fluorinated surfactant, wherein the specific surfactant is contained in an amount of 10 ppm or larger but less than 100 ppm in terms of mass ppm of the solid components of the composition and has an HLB value of 10 or greater. The method for producing a vinylidene-fluoride-based polymer according to the present invention comprises emulsion-polymerizing specific monomers in an aqueous medium in the presence of a specific emulsifier and an initiator without using any fluorinated surfactant, the use amount of the emulsifier being 8.5 ppm or larger but less than 100 ppm in terms of mass ppm of the monomers.

Embodiments in accordance with the present invention encompass compositions comprising an organopalladium compound, a photoacid generator, a photosensitizer, one or more epoxy group containing olefinic monomers. The compositions of this invention may additionally contain one or more olefinic monomers and a stabilizer, such as for example a hindered amine. The compositions undergo simultaneous vinyl addition polymerization and cationic polymerization when exposed to a suitable actinic radiation to form a substantially transparent film. The compositions of this invention are stable at room temperature for several days to several months and undergo mass polymerization only when subjected to suitable actinic radiation. The monomers employed therein have a range of optical and mechanical properties, and thus these compositions can be tailored to form films having various opto-electronic properties. More specifically, the compositions of this invention undergo much faster mass polymerization and exhibit superior thermo-mechanical properties when compared with the compositions containing only the olefinic monomers. Accordingly, compositions of this invention are useful in various applications, including as coatings, encapsulants, fillers, leveling agents, sealants, adhesives, among others.

Disclosed are a multifunctionalized polyethylene glycol derivative and a preparation method therefor. The derivative has an H-shaped structure as represented by formula (1) and comprises one linear core LPEG and four PEG branch chains, where n.sub.1, n.sub.2, n.sub.3, and n.sub.4 respectively are the degrees of polymerization of the branch chains, U.sub.1 and U.sub.2 are trivalent branching groups connecting the core LPEG to two of the PEG branch chains, F.sub.1 and F.sub.2 contain a functional group or a protected form R.sub.01 thereof and may or may not contain a branched group G, correspondingly, the number of R.sub.01 is one or more, F.sub.1 and F.sub.2 are either identical or different, any one linking group in the molecule or any linking group formed with an adjacent heteroatom group can either remain stable or be degraded, and any one PEG segment in the molecule is discretely polydispersed or monodispersed. The multifunctional polyethylene glycol is flexible and diverse in terms of branch structures and the lengths of branching arms, has various parameters and performance indicators that are adjustable and easy to control, and has a broad applicability.

Disclosed are hydrogel compositions that can be used to deliver therapeutic agents, including therapeutic proteins, to patients in need thereof. In an embodiment, the therapeutic agent is an immune checkpoint blockade antibody, and the hydrogel is a thermoresponsive polymer crosslinked with a hydrophilic polymer.

The present invention provides an ethylene/glycidyl acrylate copolymer aqueous dispersion composition ensuring an obtained film (e.g., coating film) with excellent adhesion, and high stability of the film itself.

Specifically, the present invention provides an ethylene/glycidyl acrylate copolymer aqueous dispersion composition, comprising: (A) an ethylene/glycidyl acrylate copolymer, (B1) an ethylene oxide/propylene oxide copolymer, (B2) a polyoxyalkylene-based non-ionic surfactant, (C) an alkali-soluble acrylic resin emulsion, and (D) a basic substance, wherein (B1) and (B2) are present in a total amount of 5 to 15 parts by mass, and (C) is present in an amount of 0.1 to 50 parts by mass per 100 parts by mass of (A), and (D) is present in an amount of 0.01 to 0.2 parts by mass per part by mass of (C).

This invention relates to improved flexible foams prepared from polymer polyols and to a process for preparing these improved flexible foams.