The present invention relates to the unexpected discovery of a cross-linked polymer of 2-hydroxyethyl methacrylate and dipicolylamine-containing monomers that can be used as a therapeutic lens to treat ocular diseases or disorders associated with matrix metalloproteinase (MMP) over-activity and/or over-expression, such as but not limited to corneal melting (or keratolysis).

The present invention relates to formulations for impregnating a porous sintered material and the use as well as methods for impregnating a porous sintered material. More specifically, the present invention relates to formulations for impregnating a porous sintered material, said formulation comprising 40-90 wt.-% of an acrylic monomer, 0.1-10 wt.-% of a radicalic thermal initiator, 0.1-10 wt.-% of a radicalic photoinitiator, 0-30 wt.-% of an organosilane adhesion promoter and 0-5 wt.-% of a siliconic surfactant. Further the invention relates also to a method for impregnating a porous sintered material, comprising the steps of dipping the porous material into a liquid formulation comprising an acrylic monomer; a radicalic thermal initiator; and a radicalic photoinitiator; vacuum treating of the dipped porous material; removing of excess liquid from the surface of the porous material; exposing of the porous material to light radiation; and heat treating of the porous material.

A BAK removal device is constructed as a plug of microparticles of a hydrophilic polymeric gel that displays a hydraulic permeability greater than 0.01 Da. The polymer hydrophilic polymeric gel comprises poly(2-hydroxyethyl methacrylate) (pHEMA). The particles are 2 to 100 μm and the plug has a surface area of 30 mm.sup.2 to 2 mm.sup.2 and a length of 2 mm to 25 mm and wherein the microparticles of a hydrophilic polymeric gel has a pore radius of 3 to 60 μm.

Reaction mixtures, foams prepared from the reaction mixtures, articles containing the foams, and methods of making the foams are provided. The polymeric material in the foam is formed from a polymerizable composition that includes a di(meth)acrylate oligomer and a monomer having a single ethylenically unsaturated group. The foams are highly filled (e.g., at least 60 volume percent of the foam is the filler) and can be thermally conductive. Although the foams contain a large amount of filler, the foams can be compressed at least 40 volume percent with an applied pressure of 50 pounds per square inch (345 kiloPascals).

Provided herein are compositions comprising: a scaffold polymer having one or more acryloyl groups or one or more methacryloyl groups; optionally a porogen and a crosslinking agent, compositions that upon crosslinking form a hydrogel for use in cell encapsulation and methods for immunocytochemistry of encapsulated cells. Scaffold polymers used are selected from: Poly(ethylene glycol) diacrylate (PEGDA); Poly(ethylene glycol) dimethylacrylate (PEGDMA); Poly(ethylene glycol) methyl ether acrylate (PEGMEA); Poly(ethylene glycol) methacrylate (PEGMA); and Poly(ethylene glycol) methyl ether methacrylate (PEGMEMA), and porogens selected from: Poly(ethylene glycol) (PEG); Chitosan; Agarose; Dextran; Hyaluronic acid; Poly(methyl methacrylate) (PMMA); Cellulose and derivatives thereof; Gelatin and derivatives thereof; and Acrylamide and derivatives thereof. The invention also provides, at least in part, compositions for forming a porous hydrogel around a cell suitable for immunostaining of cells within the hydrogel.

A porous membrane comprising a membrane-forming polymer (A) and a polymer (B) containing a methyl methacrylate unit and a hydroxyl group-containing (meth)acrylate (b1) unit. A flux of pure water to permeate the porous membrane is preferably 10 (m.sup.3/m.sup.2/MPa/h) or more and less than 200 (m.sup.3/m.sup.2/MPa/h). The contact angle of the bulk of the membrane-forming polymer (A) is preferably 60° or more. The membrane-forming polymer (A) is preferably a fluorine-containing polymer. The polymer (B) is preferably a random copolymer.

An adhesive article is described comprising a foamed adhesive layer and a non-foamed adhesive layer. The adhesive of each adhesive layer comprises a tetrahydrofurfuryl (meth)acrylate copolymer; an epoxy resin; a polyether polyol; and optionally a hydroxy-functional film-forming polymer. The adhesive may be used in structural and semi-structural bonding applications and is designed to fail cohesively.

This invention provides preparations, compositions, products, and applications of photo-crosslinked hydrogels. Component A—a photosensitive polymer derivative, component B—the photoinitiator, and auxiliary component C—other biocompatible polymer derivative each are respectively dissolved in a biocompatible medium to obtain solution A, solution B, and solution C. The solution A, the solution B, and the optional solution C are mixed homogenously to obtain a hydrogel precursor solution. The hydrogel precursor solution is subject to irradiation of the UV light for photocoupled crosslinking to form a photo-crosslinked hydrogel. The photo-crosslinked hydrogel exhibit rapid speed of photo-curing, strong tissue adhesion, excellent mechanical properties, good biocompatibility, and excellent clinical operability. In addition, this invention also provides a kit for making the photo-crosslinked hydrogel, and applications thereof in tissue engineering, regenerative medicine, 3D printing, and as a carrier of cell, protein, or drug.

Zwitterionic double network hydrogels, methods for making zwitterionic double network hydrogels, methods for using zwitterionic double network hydrogels, and articles made from and coated with zwitterionic double network hydrogels.

Provided are a decorative film for molding including a cholesteric liquid crystal layer on a base material, in which the cholesteric liquid crystal layer is a layer formed by curing a liquid crystal composition which includes, with respect to a total solid content of the liquid crystal composition, 25% by mass or more of a cholesteric liquid crystal compound having one ethylenic unsaturated group or one cyclic ether group; a molded product using the decorative film for molding; and a molding method.