A process for producing an aqueous composition comprising a dispersed esterified cellulose ether comprises the steps of grinding, in the presence of an aqueous diluent an esterified cellulose ether comprising (i) groups of the formula C(O)RCOOA or (ii) a combination of aliphatic monovalent acyl groups and groups of the formula C(O)RCOOA, wherein R is a N divalent aliphatic or aromatic hydrocarbon group and A is hydrogen or a cation, blending a salt of a fatty acid with the esterified cellulose ether and choosing the amounts of aqueous diluent, esterified cellulose ether and salt of a fatty acid that the produced aqueous composition comprises at least 20 percent of the dispersed esterified cellulose ether and heating the aqueous composition to a temperature of from 37 to 80 C during or after the grinding step.

A hair fixative composition includes at least one carboxylated cellulose ether based polyglucose polymer, an alcohol based solvent system, and a cosmetically acceptable additive, wherein the polyglucose polymer is soluble in the alcohol based solvent system. The polyglucose polymer is obtained by reacting at least one cellulose ether with at least one anhydride.

A hair fixative composition includes at least one carboxylated cellulose ether based polyglucose polymer, an alcohol based solvent system, and a cosmetically acceptable additive, wherein the polyglucose polymer is soluble in the alcohol based solvent system. The polyglucose polymer is obtained by reacting at least one cellulose ether with at least one anhydride.

Provided are a composition for hot-melt extrusion which can be hot-melt extruded at a temperature lower than a conventional temperature and therefore free of heat-induced deactivation of a drug; and a method for producing a hot-melt extrusion product which is simpler than a spray-drying method. More specifically, provided is a composition for hot-melt extrusion including a drug and hypromellose acetate succinate (HPMCAS) having a hydroxypropoxy molar substitution of 0.40 or more. Also provided is a method for producing a hot-melt extrusion product including a step of hot-melt extruding a composition for hot-melt extrusion including a drug and hypromellose acetate succinate having a hydroxypropoxy molar substitution of 0.40 or more at a hot-melt temperature of melting temperature of the hypromellose acetate succinate or higher, or at a hot-melt temperature equal to or higher than a temperature at which both the hypromellose acetate succinate and the drug become melted.

Provided are a composition for hot-melt extrusion which can be hot-melt extruded at a temperature lower than a conventional temperature and therefore free of heat-induced deactivation of a drug; and a method for producing a hot-melt extrusion product which is simpler than a spray-drying method. More specifically, provided is a composition for hot-melt extrusion including a drug and hypromellose acetate succinate (HPMCAS) having a hydroxypropoxy molar substitution of 0.40 or more. Also provided is a method for producing a hot-melt extrusion product including a step of hot-melt extruding a composition for hot-melt extrusion including a drug and hypromellose acetate succinate having a hydroxypropoxy molar substitution of 0.40 or more at a hot-melt temperature of melting temperature of the hypromellose acetate succinate or higher, or at a hot-melt temperature equal to or higher than a temperature at which both the hypromellose acetate succinate and the drug become melted.

Esterified cellulose ethers which comprise (i) groups of the formula C(O)RCOOA or (ii) a combination of aliphatic monovalent acyl groups and groups of the formula C(O)RCOOA, wherein R is a divalent aliphatic or aromatic hydrocarbon group and A is hydrogen or a cation, which have a viscosity of up 50 mPa.Math.s, measured as a 10 wt % solution of the esterified cellulose ether in acetone at 20 C., and a weight average molecular weight M.sub.w of at least 220,000 Dalton, or which have a viscosity of up 100 mPa.Math.s, measured as a 10 wt % solution of the esterified cellulose ether in acetone at 20 C., and a weight average molecular weight M.sub.w of at least 310,000 Dalton are useful for preparing solid dispersions comprising drugs.

Esterified cellulose ethers which comprise (i) groups of the formula C(O)RCOOA or (ii) a combination of aliphatic monovalent acyl groups and groups of the formula C(O)RCOOA, wherein R is a divalent aliphatic or aromatic hydrocarbon group and A is hydrogen or a cation, which have a viscosity of up 50 mPa.Math.s, measured as a 10 wt % solution of the esterified cellulose ether in acetone at 20 C., and a weight average molecular weight M.sub.w of at least 220,000 Dalton, or which have a viscosity of up 100 mPa.Math.s, measured as a 10 wt % solution of the esterified cellulose ether in acetone at 20 C., and a weight average molecular weight M.sub.w of at least 310,000 Dalton are useful for preparing solid dispersions comprising drugs.

The present invention relates to a gel composition comprising a glucan and a gelling agent, said composition having a melting point (gel to sol) above 37 C., as well as to the uses of this composition in therapy, in particular in wound healing.

The present invention relates to a gel composition comprising a glucan and a gelling agent, said composition having a melting point (gel to sol) above 37 C., as well as to the uses of this composition in therapy, in particular in wound healing.

The present invention relates to a cellulose composite that makes separation and aggregation less likely to occur, and, more specifically, relates to a cellulose composite comprising cellulose and one or more types of water-soluble carboxymethyl cellulose wherein tan of an aqueous dispersion obtained by dispersing 1 mass % of the cellulose composite in ion-exchanged water is 0.6 or lower.