An aqueous composition comprising: (1) an alkyl cellulose ether, and (2) an acrylic polymer comprising polymerized units of (i) 35 to 65 wt % C.sub.1-C.sub.4 alkyl acrylates; (ii) 30 to 60 wt % C.sub.3-C.sub.6 carboxylic acid monomers; and (iii) 2 to 10 wt % of monomers having an alkyl group having at least ten carbon atoms.

The present invention relates to a sustained-release formulation comprising a metastin derivative and a lactic polymer having a weight average molecular weight of about 5,000 to about 40,000 or a salt thereof. The sustained-release formulation of the present invention slowly and stably releases compound (I) or a salt thereof over a long period of time and exerts medicinal effects of compound (I) or a salt thereof over a long period of time. Furthermore, the sustained-release formulation of the present invention, which improves patient's convenience by reducing frequency of administration, is an excellent formulation as a clinical medicine.

The present invention relates to a sustained-release formulation comprising a metastin derivative and a lactic polymer having a weight average molecular weight of about 5,000 to about 40,000 or a salt thereof. The sustained-release formulation of the present invention slowly and stably releases compound (I) or a salt thereof over a long period of time and exerts medicinal effects of compound (I) or a salt thereof over a long period of time. Furthermore, the sustained-release formulation of the present invention, which improves patient's convenience by reducing frequency of administration, is an excellent formulation as a clinical medicine.

Functionalized chondroitin sulfate, cross-linked polymer matrices comprising functionalized chondroitin sulfate, and methods of making and using the same are provided. Such polymer matrices may be used for tissue engineering, reconstructing cartilage, and the like. Kits are also provided for detection of cartilage degrading enzymes.

Polyphase biodegradable compositions having a good resistance to ageing comprising a continuous phase comprising at least one hydrophobic polyester and at least one dispersed phase of polymer of vegetable origin. The hydrophobic polyester constituting the continuous phase is incompatible with the polymer of vegetable origin. The compositions comprise a plasticiser comprising at least 75% of a mixture of diglycerol, triglycerol and tetraglycerol.

Polyphase biodegradable compositions having a good resistance to ageing comprising a continuous phase comprising at least one hydrophobic polyester and at least one dispersed phase of polymer of vegetable origin. The hydrophobic polyester constituting the continuous phase is incompatible with the polymer of vegetable origin. The compositions comprise a plasticiser comprising at least 75% of a mixture of diglycerol, triglycerol and tetraglycerol.

Polyphase biodegradable compositions having a good resistance to ageing comprising a continuous phase comprising at least one hydrophobic polyester and at least one dispersed phase of polymer of vegetable origin. The hydrophobic polyester constituting the continuous phase is incompatible with the polymer of vegetable origin. The compositions comprise a plasticizer comprising at least 75% of a mixture of diglycerol, triglycerol and tetraglycerol.

Polyphase biodegradable compositions having a good resistance to ageing comprising a continuous phase comprising at least one hydrophobic polyester and at least one dispersed phase of polymer of vegetable origin. The hydrophobic polyester constituting the continuous phase is incompatible with the polymer of vegetable origin. The compositions comprise a plasticizer comprising at least 75% of a mixture of diglycerol, triglycerol and tetraglycerol.

The invention describes a double-sided, carrierless self-adhesive tape which can be used in particular for achieving very durable adhesive bonding of a variety of articles. This double-sided, carrierless self-adhesive tape is composed of a homogeneously crosslinked pressure-sensitive acrylate hotmelt composition of single-layer construction, which may have been lined with release materials such as siliconized release papers or release films. The double-sided, carrierless pressure-sensitive adhesive tape is characterized in that it is composed of a photoinitiator-free, thermally homogeneously crosslinked acrylate hotmelt which is crosslinked predominantly by way of urethane units. It is notable in particular for the fact that it is homogeneously chemically crosslinked through the layer and, in contrast to acrylate layers crosslinked by radiation (UV/EBC), does not exhibit any profile of crosslinking through the layer. It can be used in particular as an adhesive transfer tape for the permanent attachment of articles to a variety of substrates.

The invention describes a double-sided, carrierless self-adhesive tape which can be used in particular for achieving very durable adhesive bonding of a variety of articles. This double-sided, carrierless self-adhesive tape is composed of a homogeneously crosslinked pressure-sensitive acrylate hotmelt composition of single-layer construction, which may have been lined with release materials such as siliconized release papers or release films. The double-sided, carrierless pressure-sensitive adhesive tape is characterized in that it is composed of a photoinitiator-free, thermally homogeneously crosslinked acrylate hotmelt which is crosslinked predominantly by way of urethane units. It is notable in particular for the fact that it is homogeneously chemically crosslinked through the layer and, in contrast to acrylate layers crosslinked by radiation (UV/EBC), does not exhibit any profile of crosslinking through the layer. It can be used in particular as an adhesive transfer tape for the permanent attachment of articles to a variety of substrates.