An object of the present invention is to provide a cancer cell inhibitory drug, particularly a cancer stem-cell inhibitory drug, or a cancer stem-cell detection probe. The present invention provides a cancer cell inhibitory drug comprising at least one compound represented by general formula (1) as an active ingredient ##STR00001##

The invention provides agents that target carbonic anhydrase, which can be used as imaging agents or therapeutic agents. The agents can be used to image tumor hypoxia as well as other physiological processes in a subject.

The present invention relates to a novel organic compound, a near-infrared fluorescent constant medium containing the same, and a method for nano-granulating the constant medium.

The composition includes two or more near infrared absorbing compounds having an absorption maximum in a wavelength range of 650 to 1000 nm and having a solubility of 0.1 mass % or lower in water at 23? C., in which the two or more near infrared absorbing compounds include a first near infrared absorbing compound having an absorption maximum in a wavelength range of 650 to 1000 nm, and a second near infrared absorbing compound having an absorption maximum in a wavelength range of 650 to 1000 nm which is shorter than the absorption maximum of the first near infrared absorbing compound, and a difference between the absorption maximum of the first near infrared absorbing compound and the absorption maximum of the second near infrared absorbing compound is 1 to 150 nm.

Provided herein are compounds that are able to bind metal ions (e.g., free metal ions or metal ions bound to low affinity ligands) in a sample or subject. Also provided herein are methods of using the compounds for chelating metal ions and for the treatment of diseases associated with abnormal levels of metal ions. Methods of preparing the compounds and pharmaceutical compositions are also provided.

The invention provides agents that target carbonic anhydrase, which can be used as imaging agents or therapeutic agents. The agents can be used to image tumor hypoxia as well as other physiological processes in a subject.

A positive-working lithographic printing plate precursor includes a coating optimized for producing a minimum extent of ablation when exposed to heat and/or light. The coating includes an infrared absorbing agent which contains a structural element according to Formula I:

##STR00001##

wherein A represents SR.sup.1 wherein R.sup.1 represents an optionally substituted alkyl, aralkyl, alkaryl, cycloalkyl, alkenyl, alkynyl, aryl, or heteroaryl group, and/or combinations thereof; and Q=CHRCHR, CRCR or CHRCHRCHR and R, R and R independently represent hydrogen, an alkyl, cycloalkyl, aralkyl, alkaryl, aryl or heteroaryl group, or R and R or R and R form together a cyclic structure.

The invention provides a novel class of cyanine dyes that are functionalized with a linker moiety that facilitates their conjugation to other species and substituent groups which increase the water-solubility, and optimize the optical properties of the dyes. Also provided are conjugates of the dyes, methods of using the dyes and their conjugates and kits including the dyes and their conjugates.

Disclosed is a dye-sensitized solar cell which includes a working electrode and a counter electrode facing each other with an electrolyte layer therebetween, the working electrode having a dye-supporting metal oxide electrode composed of a metal oxide layer having a dye supported thereon. The dye contains a cyanine dye, and the electrolyte of the electrolyte layer contains a cobalt-based electrolyte. It is preferred to use at least one cyanine dye represented by general formula (1) as the cyanine dye. An.sup.q? represents a q-valent anion, wherein q represents 1 or 2, and p represents a coefficient for maintaining overall charge neutrality.

Infrared dyes having an infrared absorption maximum above 1130 nm with minor colouration in the visual spectrum. The infrared dyes are especially useful for producing multicolour laser marked security documents having reduced background coloration and enhanced colour gamut.