A color vision correction filter includes a least one type of dye material and the lowest value of transmittance of the color vision correction filter in a wavelength band ranging from 440 nm to 600 nm, inclusive, is in the range of plus or minus 50 nm of 535 nm.

Provided is a cyanine compound being bound counterions consisting of an anion and a cation, wherein the anion is represented by the following formula (I-1):

##STR00001##

wherein R.sup.1 and R.sup.2 each independently represent a hydrogen atom or a monovalent organic group; R.sup.3 and R.sup.4 each independently represent a monovalent group such as a phenyl group; X represents a hydrogen atom, a halogen atom or a monovalent organic group; and Y represents a divalent group such as a n-propenyl group.

Disclosed herein are compounds, conjugates, and methods that may be used to detect the presence of an analyte in a sample, such as a biological sample.

The invention provides a compound of formula (I): wherein R1, R2, and R3 have any of the values described in the specification, as well as compositions comprising a compound of formula (I), methods for preparing compounds of formula (I), and methods for detecting the presence of an amine in a sample. The compounds are useful as pigments.

The invention provides a compound of formula (I): wherein R1, R2, and R3 have any of the values described in the specification, as well as compositions comprising a compound of formula (I), methods for preparing compounds of formula (I), and methods for detecting the presence of an amine in a sample. The compounds are useful as pigments.

Provided are any one of the following compounds and a fluorescently labeled biological substance having this compound.

##STR00001##

R.sup.1 to R.sup.27, L.sup.11, L.sup.12, and X.sup.+ represent a specific group, and at least one of R.sup.1 to R.sup.4 represents a substituted alkyl group.

In a case where at least one of R.sup.1 to R.sup.4 is an alkyl group having a carboxy group or a substituent capable of being bonded to a biological substance, at least one of R.sup.11 to R.sup.27 is an alkyl group or an aryl group, or at least one of R.sup.1 to R.sup.4, which does not correspond to the alkyl group having a carboxy group or an alkyl group having a substituent capable of being bonded to a biological substance, is an alkyl group having a sulfoalkyl group through a single bond or a linking group.

The total of n1 to n4 is an integer of 3 or more, and m=n1+n2+n3+n4−1 is satisfied.

At least one of R.sup.1 to R.sup.4, R.sup.13, L.sup.11 or L.sup.12 in Formula (1) and at least one of R.sup.1 to R.sup.4, R.sup.24, L.sup.11, or L.sup.12 in Formula (2) have a specific substituent.

Provided are any one of the following compounds and a fluorescently labeled biological substance having this compound.

##STR00001##

R.sup.1 to R.sup.27, L.sup.11, L.sup.12, and X.sup.+ represent a specific group, and at least one of R.sup.1 to R.sup.4 represents a substituted alkyl group.

In a case where at least one of R.sup.1 to R.sup.4 is an alkyl group having a carboxy group or a substituent capable of being bonded to a biological substance, at least one of R.sup.11 to R.sup.27 is an alkyl group or an aryl group, or at least one of R.sup.1 to R.sup.4, which does not correspond to the alkyl group having a carboxy group or an alkyl group having a substituent capable of being bonded to a biological substance, is an alkyl group having a sulfoalkyl group through a single bond or a linking group.

The total of n1 to n4 is an integer of 3 or more, and m=n1+n2+n3+n4−1 is satisfied.

At least one of R.sup.1 to R.sup.4, R.sup.13, L.sup.11 or L.sup.12 in Formula (1) and at least one of R.sup.1 to R.sup.4, R.sup.24, L.sup.11, or L.sup.12 in Formula (2) have a specific substituent.

The present invention relates to the field of optical imaging More particularly, it relates to compounds of the cyanine family characterized by improved physico-chemical and biological properties and to their conjugates with biological ligands thereof. The invention also relates to the use of these compounds as optical diagnostic agents in imaging or therapy of solid tumors, to the methods for their preparation and to the compositions comprising them.

The present invention relates to the field of optical imaging More particularly, it relates to compounds of the cyanine family characterized by improved physico-chemical and biological properties and to their conjugates with biological ligands thereof. The invention also relates to the use of these compounds as optical diagnostic agents in imaging or therapy of solid tumors, to the methods for their preparation and to the compositions comprising them.

This disclosure provides cyanine dye compounds having linked hydrogen bond-forming groups that can be used for detecting nucleic acids, particularly for fluorescent staining of DNA, in a biological sample. We found that the simultaneous incorporation of at least two hydrogen bond-forming groups (HBGs) into such a nucleic acid stain can provide for crosslinking interactions between the stain and the target nucleic acid, and lead to a significant increase in the detection sensitivity without substantially increasing undesirable cytotoxicity or mutagenicity properties of the dye compounds. The cyanine dye compounds can have a cyanine structure that connects two particular fused heterocycle ring systems, where at least two HBGs are connected to the core structure through linkers. Also provided are nucleic acid complexes including the cyanine dye compounds, and methods of using the compounds to detect nucleic acids in a biological sample.