The present invention relates to an optical filter containing: an absorption layer containing a near-infrared absorbing dye (A) having a maximum absorption wavelength in dichloromethane being in a wavelength range of 850 to 1,100 nm and a transparent resin; and a reflection layer formed of a dielectric multilayer film, in which the near-infrared absorbing dye (A) satisfies the following Formulae (1) to (4).
ABS.sub.400(A)DCM/ABS.sub.max(A)DCM<0.10(1),
ABS.sub.550(A)DCM/ABS.sub.max(A)DCM<0.04(2),
ABS.sub.400(A)TR/ABS.sub.max(A)TR<0.15(3), and
ABS.sub.550(A)TR/ABS.sub.max(A)TR<0.10(4).

Disclosed herein, inter alia, are detectable compounds including a triplet state quencher and the method of use thereof.

The present invention relates to an optical filter, a solid-state imaging element and an imaging device lens which contain a near infrared ray absorbing layer having a specific near infrared ray absorbing dye dispersed in a transparent resin having a refractive index of 1.54 or more, and also relates to an imaging device containing the solid-state imaging element or the imaging device lens. The near infrared ray absorbing layer has a transmittance of visible light of from 450 to 600 nm of 70% or more, a transmittance of light in a wavelength region of from 695 to 720 nm of not more than 10%, and an amount of change of transmittance of not more than 0.8.

The present invention relates to an optical filter containing: an absorption layer containing a near-infrared absorbing dye (A) having a maximum absorption wavelength in dichloromethane being in a wavelength range of 850 to 1,100 nm and a transparent resin; and a reflection layer formed of a dielectric multilayer film, in which the near-infrared absorbing dye (A) satisfies the following Formulae (1) to (4).

[00001]$\begin{array}{cc}\mathrm{AB}{S}_{400\left(A\right)\mathrm{DCM}}/\mathrm{AB}{S}_{\max \left(A\right)\mathrm{DCM}}<0.1,& \left(1\right)\end{array}$$\begin{array}{cc}\mathrm{AB}{S}_{550\left(A\right)\mathrm{DCM}}/\mathrm{AB}{S}_{\max \left(A\right)\mathrm{DCM}}<0\text{.04},& \left(2\right)\end{array}$$\begin{array}{cc}\mathrm{AB}{S}_{400\left(A\right)\mathrm{TR}}/\mathrm{AB}{S}_{\max \left(A\right)\mathrm{TR}}<0.15,\mathrm{and}& \left(3\right)\end{array}$

An object of this invention is to provide a streptavidin mutant reduced in affinity to the naturally-occurring biotin, and to provide a modified biotin which shows a high affinity to such streptavidin mutant reduced in affinity to the naturally-occurring biotin. This invention can provide a compound composed of a dimer of modified biotin, a streptavidin mutant, and usage of them.

The present invention provides novel compounds and methods for hydrocyanines derived from near-infrared cyanine dyes, as reactive oxygen species probes in imaging. In certain embodiments, the present invention provides reduced dyes as substrates for ELISA and Western blots.

The present invention provides a method of optical electrophysiological probing, including: providing a fluorescing chemical probe; contacting a thick portion of tissue with the fluorescing chemical probe to create a thick portion of treated tissue; applying a first range of wavelengths of electromagnetic radiation to the treated portion of tissue; and detecting a plurality of depth-specific emission wavelengths emitted from the thick portion of treated tissue.

The present invention relates generally to substrates for making polymers and methods for making polymers. The present invention also relates generally to polymers and devices comprising the same.

An imaging device, comprising: an infrared light absorption layer including a cyanine dye represented by Chemical Formula (A) below: wherein R.sub.1 and R.sub.2 are selected from the group consisting of: a chain alkyl group,a cyclic alkyl group, a phenyl group, and a benzyl group; wherein the chain alkyl group and the cyclic alkyl group including at least one group member selected from the group consisting of: 1) a first group having one or more hydrogen atoms in a first alkyl group substituted with at least one functional group selected from the group consisting of: a halogen atom, an alkoxy group, an alkanoloxy group, an amino group, a thiol group, and a mercapto group; 2) a second group having at least one reactive group selected from the group consisting of: a vinyl group, an acrylic group, a carbonyl group, a carboxyl group, an alkenyl group, an alkenyloxy group, an alkoxycarbonyl group, a nitrile group, a carboxyl group, a carbonyl group, a sulfonyl group, a sulfamoyl group, a carbamoyl group, a benzoyloxy group, and a cyano group,wherein the reactive group is any one of introduced at a terminal alkyl group of at least one of the chain alkyl group and the cyclic alkyl group and positioned two or more carbon atoms away from an indoline ring; 3)an unsubstituted chain alkyl group; and 4) an unsubstituted cyclic alkyl group; and wherein X.sup. represents an anion.

Provided is a coloring composition containing a coloring agent compound represented by Formula 1 and a medium. ##STR00001## Description of T.sup.1, T.sup.2, R.sup.1, R.sup.2, X.sup.1, and n Formula 1 are omitted.