A compound represented by Formula (I) or a salt thereof. In Formula (I), Ar represents a substituted or unsubstituted C6 to C10 aryl group or the like, L.sup.1 represents a single bond or the like, L.sup.2 represents a single bond or the like, X.sup.1 represents a cyano group or the like, X.sup.2 represents a hydrogen atom or the like, X.sup.3 represents a halogeno group or the like, A represents a nitrogen atom or the like, R.sup.1 represents a hydrogen atom or the like, R.sup.2a represents a substituted or unsubstituted C1 to C6 alkyl group and R.sup.2b represents a hydrogen atom or the like, where R.sup.2a and R.sup.2b may be combined with each other to form a substituted or unsubstituted C2 to C5 alkylene group, and Y represents a substituted or unsubstituted C1 to C6 alkyl group or the like.

##STR00001##

A compound represented by Formula (I) or a salt thereof. In Formula (I), Ar represents a substituted or unsubstituted C6 to C10 aryl group or the like, L.sup.1 represents a single bond or the like, L.sup.2 represents a single bond or the like, X.sup.1 represents a cyano group or the like, X.sup.2 represents a hydrogen atom or the like, X.sup.3 represents a halogeno group or the like, A represents a nitrogen atom or the like, R.sup.1 represents a hydrogen atom or the like, R.sup.2a represents a substituted or unsubstituted C1 to C6 alkyl group and R.sup.2b represents a hydrogen atom or the like, where R.sup.2a and R.sup.2b may be combined with each other to form a substituted or unsubstituted C2 to C5 alkylene group, and Y represents a substituted or unsubstituted C1 to C6 alkyl group or the like.

##STR00001##

Applicants have developed novel methods and compositions for controlling, treating, preventing, or ameliorating arthropod infection and identifying kinin receptor agonists and antagonists. Novel compositions include one or more active agents of small molecules antagonists or agonists of arthropod kinin receptor. Methods of preventing disease development and infestation by arthropods are disclosed as well as methods of making, using, and producing such compositions.

Applicants have developed novel methods and compositions for controlling, treating, preventing, or ameliorating arthropod infection and identifying kinin receptor agonists and antagonists. Novel compositions include one or more active agents of small molecules antagonists or agonists of arthropod kinin receptor. Methods of preventing disease development and infestation by arthropods are disclosed as well as methods of making, using, and producing such compositions.

Compounds of formula (I) wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts, stereoisomers, enantiomers, tautomers and N-oxides of those compounds, can be used as insecticides.

##STR00001##

Compounds of formula (I) wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts, stereoisomers, enantiomers, tautomers and N-oxides of those compounds, can be used as insecticides.

##STR00001##

The present invention provides compounds of formula (I):

##STR00001##

which are useful for long-lasting treatment and control of pests, for example fleas and ticks, in companion animals and livestock, and pharmaceutical compositions and methods of using the same.

The present invention provides compounds of formula (I):

##STR00001##

which are useful for long-lasting treatment and control of pests, for example fleas and ticks, in companion animals and livestock, and pharmaceutical compositions and methods of using the same.

The present invention relates to a use of a CYP450 inhibitor in inhibiting or killing mites and treating xerophthalmia. A large number of experiments show that the CYP450 inhibitor can be used for inhibiting or killing mites, can effectively shorten the survival time of mites, and can be used for a mite killing and inhibiting product (such as drugs, cosmetics, daily necessities, or the like). In addition, it is found that the CYP450 inhibitor may also be used in the treatment of xerophthalmia, and can effectively alleviate and improve the symptoms of xerophthalmia.

The present invention relates to seed treatment compositions comprising combinations of a compound of formula (I), wherein: R is hydrogen or fluorine; and R.sup.2 is: in which n is 0, 1 or 2: with a compound selected from a group consisting of mixing partners; and to seed treatments and methods of controlling or preventing damage to plants seed treatments comprising such combinations.

##STR00001##