The present invention provides: a photochromic curable composition which contains (A) a (meth)acrylate composition that contains from 24 to 100% by mass of a polyfunctional (meth)acrylate which has three or more (meth)acryloyl groups in each molecule and (B) a photochromic compound that is obtained by bonding at least one specific naphthopyran to a long-chain group having a number average molecular weight of from 300 to 10,000; and a photochromic optical article which is obtained by polymerizing this photochromic curable composition.

Provided are multi-chromophore dyes. Embodiments of the multi-chromophore dyes include two or more dyes each comprising a water solubilizing group, two or more polymeric spacer domains and a linking moiety. Such multi-chromophore dyes can have advantageously high brightness by including multiple dyes while also reducing the rate of self-quenching. Also provided are methods of using such dyes, as well as kits that includes such dyes.

Compounds useful as fluorescent or colored dyes are disclosed. The compounds have the following structure (I): or a stereoisomer, tautomer or salt thereof, wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, L, L.sup.1, L.sup.2, L.sup.3, L.sup.4, M, M′, m.sup.1, m.sup.2, n, x, y and z are as defined herein. Methods associated with preparation and use of such compounds are also provided. ##STR00001##

Compounds useful as fluorescent or colored dyes are disclosed. In some embodiments, the compounds have the following structure (I):

##STR00001##

or a stereoisomer, tautomer or salt thereof, wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, L.sup.1, L.sub.2, L.sub.3, L.sup.4, M.sup.1, M.sup.2, m, and n are as defined herein. Methods associated with preparation and use of such compounds is also provided.

Compounds useful as fluorescent or colored dyes are disclosed. The compounds have the following structure (I):

##STR00001##

including stereoisomers, salts and tautomers thereof, wherein R.sup.1, R.sup.2, R.sup.3, L.sup.1, L.sup.2, L.sup.3, L.sup.4, L.sup.5, L.sup.6, M.sup.1, M.sup.2, A, q, w and n are as defined herein. Methods associated with preparation and use of such compounds are also provided.

A quencher is disclosed having a compound represented by the following general formula (1):

##STR00001##

wherein R.sub.5 each independently represent a halogen atom, an alkyl group, an alkoxy group, an alkylthio group, an amino group having a substituent or not having a substituent, a hydroxy group, an aryl group, an aryloxy group, or an arylalkyl group; R.sub.6 represents a group having a polymerizable unsaturated group, a hydroxy group, or the like; Y.sub.1 represents an oxygen atom, or the like; An.sup.− represents an anion; Ar.sub.1 represents a specific ring structure; * and ** represent binding positions; Ar.sub.2 represents a benzene ring, a naphthalene ring, or an anthracene ring; n.sub.1 represents a specific integer;
and the following structure (1-10) in the general formula (1) is an asymmetric structure;

##STR00002##

(wherein R.sub.5, Y.sub.1, Ar.sub.1, Ar.sub.2, n.sub.1, * and ** are the same as described above.).

A composition comprising: (a) a leuco composition; and (b) a stabilizing amount of an antioxidant composition. The antioxidant composition comprises at least one sterically hindered phenol and at least one substituted diarylamine, and the mole ratio of the hindered phenol to the substituted diarylamine is greater than 1:1. In another embodiment, a composition comprises (a) a leuco composition and (b) an antioxidant composition; and optionally (c) a solvent composition. The combined mass of the leuco compounds and antioxidants present in the composition is 10% or more of the total mass of the composition, and (b) the molar ratio of antioxidants present in the composition to leuco compounds present in the composition is greater than 1:1.

Compounds useful as fluorescent or colored dyes are disclosed. The compounds have the following structure (I):

##STR00001##

or a stereoisomer, tautomer or salt thereof, wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, L.sup.1, L.sup.2, L.sup.3, L.sup.4, M, m and n are as defined herein. Methods associated with preparation and use of such compounds are also provided.

Provided is a compound represented by formula (I), which can be used as a fluorescent probe that becomes highly fluorescent only in an intracellular acidic environment and can be adapted to the fluorescent imaging of an intracellular vesicle that is a microstructure. ##STR00001## In the formula, R.sub.1 and R.sub.2 independently represent a hydrogen atom, or an alkyl group which may be substituted (wherein R.sub.1 and/or R.sub.2 represents an alkyl group which may be substituted); R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7 and R.sub.8 independently represent a hydrogen atom, a halogen atom, or the like; X represents a functional group to which a labeling site or a target-accumulating site can be introduced, or the like; Y represents a halogen atom, an alkyl group which may be substituted, or the like; m represents an integer of 0 to 5; and n represents an integer of 0 to 5.

The present invention relates to an at least partly implantable system for injecting a substance into a patient's body. The system comprises at least one implantable infusion needle arranged in at least one first housing, the at least one implantable infusion needle having a tip end for injecting a substance into a penetration area of a patient, and at least one drive unit coupled to the at least one implantable infusion needle and arranged for moving the tip end of the at least one infusion needle for varying the penetration site, wherein the at least one drive unit is a drive unit arranged for moving the tip end of the at least one infusion needle using hydraulic force. The system is adapted to use infusion liquid to be injected into the patient's body as hydraulic fluid.