The invention provides a cell culture vessel with a coating which inhibits adhesion of a peptide relating to cell proliferation on at least a part of the surface thereof. The coating desirably contains a copolymer containing a recurring unit which contains a group represented by formula (a) and a recurring unit which contains a group represented by formula (b).

##STR00001##

wherein U.sup.a1, U.sup.a2, U.sup.a3, U.sup.b1, U.sup.b2, U.sup.b3 and An.sup.− are as defined herein.

The present invention provides a coating fluid for forming a gas barrier layer, the coating fluid including; a liquid medium containing water; and a resin having at least one type of functional group selected from the group consisting of a hydroxy group, a carboxy group, an amino group, and a sulfo group, in which an average particle size of the resin is 100 to 600 nm.

A device includes a substrate and a hydrophilic polymer layer made of a hydrophilic polymer having a hydroxyl group. The hydrophilic polymer layer having a hydroxyl group is fixed to at least a part of a surface of the substrate and the hydrophilic polymer further has an amide group. A liquid film retention time of the device is 15 seconds or more. The device has a surface of a substrate which is hydrophilized. A method for producing the device by a simple method is also disclosed.

antifogging agent including silica particles, a hinder compound, a silane coupling agent having a polyether group, and a liquid medium.

antifogging agent including silica particles, a hinder compound, a silane coupling agent having a polyether group, and a liquid medium.

The invention provides a coating agent for a flow passage which comprises a copolymer containing a recurring unit which contains an organic group of the formula (a) ##STR00001##
wherein U.sup.a1 and U.sup.a2 are defined herein, and a recurring unit which contains an organic group of the formula (b) ##STR00002##
wherein U.sup.b1, U.sup.b2, U.sup.b3, and An.sup. are defined herein. The invention also provides a flow passage device having the coating agent for a flow passage on at least part of an inner surface of a flow passage, a platelet-producing flow passage device and a method for manufacturing the same.

The invention provides a coating agent for a flow passage which comprises a copolymer containing a recurring unit which contains an organic group of the formula (a) ##STR00001##
wherein U.sup.a1 and U.sup.a2 are defined herein, and a recurring unit which contains an organic group of the formula (b) ##STR00002##
wherein U.sup.b1, U.sup.b2, U.sup.b3, and An.sup. are defined herein. The invention also provides a flow passage device having the coating agent for a flow passage on at least part of an inner surface of a flow passage, a platelet-producing flow passage device and a method for manufacturing the same.

A method for producing an acrylic resin-coated silica particle dispersion by (1), mixing and heating silica particles (A), an organic solvent (B) and a monomer having a polymerizable unsaturated group and a hydrolyzable silyl group (C) to obtain a polymerizable unsaturated group-containing silica particle dispersion (i), (2) adding a tertiary amine (D) with a molecular weight of 120 to 380 and having a terminal alkyl and/or aryl group, to the component (i) dispersion, to obtain a polymerizable unsaturated group-containing silica particle dispersion (ii), and (3) reacting the component (ii) dispersion with a polymerizable unsaturated monomer (E), in a solid mass ratio of (ii):(E)=20:80 to 90:10, to obtain an acrylic resin-coated silica particle dispersion.

A method for producing an acrylic resin-coated silica particle dispersion by (1), mixing and heating silica particles (A), an organic solvent (B) and a monomer having a polymerizable unsaturated group and a hydrolyzable silyl group (C) to obtain a polymerizable unsaturated group-containing silica particle dispersion (i), (2) adding a tertiary amine (D) with a molecular weight of 120 to 380 and having a terminal alkyl and/or aryl group, to the component (i) dispersion, to obtain a polymerizable unsaturated group-containing silica particle dispersion (ii), and (3) reacting the component (ii) dispersion with a polymerizable unsaturated monomer (E), in a solid mass ratio of (ii):(E)=20:80 to 90:10, to obtain an acrylic resin-coated silica particle dispersion.

The present invention provides a cell culture container for long term non-adherent cell culture which comprises having a coating containing a copolymer which is a copolymer having a recurring unit which contains a group represented by the following formula (a), a recurring unit which contains a group represented by the following formula (b), and a recurring unit which contains a group represented by the following formula (c), and a molar ratio of the recurring unit which contains a group represented by the formula (c) being 1 to 50 mol % based on the whole copolymer, provided with at least a part of a surface thereof

##STR00001## [wherein, U.sup.a1, U.sup.a2, U.sup.b1, U.sup.b2 and U.sup.b3, R.sup.c, and An.sup. are as defined in the specification and Claims.]