The present invention relates to a process for the in situ regeneration of a hydroconversion catalyst. The invention also relates to a hydroconversion process comprising said regeneration process. The invention also relates to a system comprising a reaction section (40) comprising a hydroconversion reactor operating as an ebullating bed or as a moving bed; a regeneration section comprising a regeneration device (100); means for transfer of the hydroconversion catalyst between said reaction section (40) and said regeneration section comprising at least one fluidic connection; means for charging said regeneration device (100) as a fluidized bed or as a moving bed.