The present invention is generally directed to a hydrogen peroxide-based lens care system for disinfecting contact lenses. Unlike hydrogen peroxide-based system known in the prior art, a lens care system of the present invention involves electrochemically neutralizing of hydrogen peroxide after any desired period of disinfection time for which contact lenses have been immersed in a hydrogen peroxide-based lens care solution.

A contact lens treating solution includes (a) one or more of tris(hydroxymethyl)aminomethane, bis(2-hydroxyethyl)amino-tris(hydroxymethyl)methane and a salt thereof; and (b) one or more antimicrobial agents comprising one or more polyquaternium polymers.

The invention provides contact lens storage, cleaning and treatment compositions comprising nonionic surfactants. The invention further provides methods for treating enhancing contact lens wear time and comfort, reducing contact lens deposits and treating dry eye via contact lenses.

The present invention relates to an ophthalmic solution comprising 0.00001 to 10.0 weight percent of a simple saccharide, at least 0.00001 weight percent of a preservative, and not more than about 0.2 percent by weight chloride. The simple saccharide is chosen from the group consisting of: inositol; mannitol; sorbitol; sucrose; dextrose; glycerin; propylene glycol; ribose; triose; tetrose; erythrose; threose; pentose; arabinose; ribulose; xylose; xylulose; lyxose; hexose; allose; altrose; fructose; galactose; glucose; gulose; idose; mannose; sorbose; talose; tagatose; adlose; ketose; heptose; sedoheptulose; monosaccharides; disaccharides; sugar alcohols; xylitol; and polyol.

An ophthalmically compatible solution includes (a) about 0.005 to about 2 wt. %, based on the total weight of the ophthalmically compatible solution, of hyaluronic acid or a salt thereof; (b) about 0.01 to about 1 wt. %, based on the total weight of the ophthalmically compatible solution, of erythritol; (c) sodium chloride, potassium chloride or any combination thereof; and (d) one or more buffers.

A contact lens treating solution includes (a) one or more potassium salts selected from the group consisting of potassium chloride, potassium citrate, potassium hydroxide, potassium borate, potassium ethylenediaminetetraacetic acid and potassium phosphate, (b) an antimicrobial agent comprising alexidine or a salt or a free base thereof, and (c) optionally, one or more sodium salts selected from the group consisting of sodium chloride, sodium citrate, sodium hydroxide, sodium phosphate, sodium ethylenediaminetetraacetic acid and sodium borate, wherein the one or more potassium salts are present in an amount greater than an amount of the one or more sodium salts when present.

Silicone hydrogel contact lenses are packaged in a packaging solution including an ophthalmically-acceptable concentration of a surfactant to provide a contact lens having a lower coefficient of friction compared to a control lens that is not packaged in the surfactant. The surfactant is a poly(ethylene oxide) (PEO)-containing surfactant having a molecular weight of up to about 6,000 daltons, or is an alkyl aryl-containing surfactant, or is both an alkyl aryl and PEO-containing surfactant having a molecular weight of up to about 6,000 daltons. Methods of manufacturing silicone hydrogel contact lenses are also described.

The present invention relates to an ophthalmic solution comprising 0.00001 to 10.0 weight percent of a simple saccharide, at least 0.00001 weight percent of a preservative, and not more than about 0.2 percent by weight chloride. The simple saccharide is chosen from the group consisting of: inositol; mannitol; sorbitol; sucrose; dextrose; glycerin; propylene glycol; ribose; triose; tetrose; erythrose; threose; pentose; arabinose; ribulose; xylose; xylulose; lyxose; hexose; allose; altrose; fructose; galactose; glucose; gulose; idose; mannose; sorbose; talose; tagatose; adlose; ketose; heptose; sedoheptulose; monosaccharides; disaccharides; sugar alcohols; xylitol; and polyol.

The present inventor has discovered how to adsorb a mitochondrially targeted compound (MTC) of general formula I on contact lenses and other matrices prior to the application of lenses or other matrix on the eye surface. After such matrix is positioned on the eye, MTC is translocated from the lens into cornea cells of the eye providing cornea protective effect and thus reducing side effects of contact lens application.

Systems and methods for cleaning a hard-coated ophthalmic lens and stripping the hard-coating of the hard coated ophthalmic lens in a single pass process are disclosed. The hard-coated ophthalmic lens is sequentially treated with a cleaning solution, an alkaline solution, and a stripping solution. Ultrasonic power is applied to the solutions and the ophthalmic lens during the process. The resulted ophthalmic lens has substantially no sign of chemical attack or residual hard coating or varnishes thereon.