An apparatus and a method for the automated processing of samples containing biological cellsin particular, of blood samples or other cell samples is provided. The apparatus has a sample receiving device configured to receive samples, an auxiliary material receiving device configured to receive auxiliary materials, a sample carrier receiving device configured to receive sample carriers, a discharge device configured to discharge samples from a discharge position, and a capture device configured to capture discharged samples in a capture position to obtain prepared samples, and at least one temperature control device for controlling the temperature of at least one of the sample carriers. The distance between the discharge position and the capture position can be adjusted to a prespecified height. The method includes wetting a temperature-controlled sample carrier with at least one auxiliary material and discharging the sample onto the wetted temperature-controlled sample carrier from a prespecified height.

An in vitro model of an in vivo gastrointestinal tract including an in vitro model of an in vivo small intestine including a plurality of fermentation vessels and an in vitro model of an in vivo large intestine including a plurality of fermentation vessels is provided. A method of simulating a biotransformation of food product through the human digestive tract using an in vitro model of an in vivo gastrointestinal tract is provided.

The present invention is related to the field of fluidic devices, and in particular, microfluidic cell culture systems. The present invention provides pumping, recirculation and sampling for a microfluidic device or devices. The present invention provides solutions to the control of microfluidics for both terrestrial and space applications, including the control over the movement of fluids in zero gravity or microgravity.

A photobioreactor for culturing light-sensitive microbes is provided, the reactor comprising a body comprising at least one floor panel and at least one wall extending upwardly around the periphery of the floor panel to define a body, wherein the at least one floor panel comprises at least one graded segment so as to define a trough along the bottom of the body towards which debris within the body flows, at least one illumination panel within the body so that there is free flow of liquid along the sides and floor panel of the body, at least one gas inlet within the trough in the floor panel, for providing an upward stream of gas into the body so as to generate air lift of the light sensitive microbes within the body. Also provided is a method for growing light-sensitive microbes.

A bag assembly for use with a heat exchanger includes a flexible bag having of one or more sheets of polymeric material, the bag having a first end that bounds a first compartment and an opposing second end that bounds a second compartment, a support structure being disposed between the first compartment and the second compartment so that the first compartment is separated and isolated from the second compartment. A first inlet port, a first outlet port, and a first drain port are coupled with the flexible bag so as to communicate with the first compartment. A second inlet port, a second outlet port, and a second drain port are coupled with the flexible bag so as to communicate with the second compartment.

The present disclosure provides a reagent cartridge configured for use in an automated multi-module cell processing environment.

Manufacturing system and method for creating multiple tissue constructs from cells. System can include a thaw subsystem (if the cells are provided in a frozen state), an expansion subsystem, a concentration subsystem, and a tissue maturation subsystem. Each of these subsystems is modular and can be reconfigured, and the process can be repeated depending on the specific tissue process being implemented. Multiple tissue types can be combined in multiple bioreactors. The activities of multiple bioreactors can be coordinated and controlled in an automated manner by a supervisor controller. The supervisor controller can receive user input at the start of the process, and can manage the process henceforth, alerting the user if user actions are required.

According to one embodiment of the present invention, a multiplex PCR device is disclosed. The multiplex PCR device comprises a multiplex PCR chip simultaneously carrying a plurality of mutually different nucleic acid molecules, and the invention may be characterised in that, attached spaced apart from each other on the multiplex PCR chip, there are a plurality of probes used for hybridization reactions whereby hybridization takes place specifically with mutually different amplified sequences of the nucleic acid molecules.

A bioreactor outlet air conditioning system (10) has a bioreactor vessel (100) and a heat exchanger. The heat exchanger has a fluid flow path (196) from a headspace (108) in the vessel for venting air from the vessel, and a temperature control element (300) in thermal contact with the fluid flow path (196). The fluid flow path (196) may be defined by a disposable portion of the bioreactor vessel (100). A method of controlling evaporation within a bioreactor vessel (100), dependent on the required evaporation rate, adjusts the temperature of the temperature control element (300) to control the rate of evaporation of the liquid media (106) from the vessel (100), and may include monitoring fluids in the fluid flow path (196) to detect at least water content of the fluids exiting the vessel to adjust the temperature and control the rate of evaporation dependent on the detected water content levels.

A photoreactor for cell assay and array chemical and biochemical reactions has a reaction chamber, an input aperture, and a lamp. A specimen receptacle with a reflective surface is positioned within the reaction chamber. The lamp has a light source, a temperature control system, and a lens. The light source is mounted onto the temperature control system and the lens is mounted onto the temperature control system. Accordingly, the temperature control system is able to moderate the temperature of the light source and the reaction chamber. The input aperture is an inlet that enables the lamp to be mounted onto the reaction chamber and retained in optical communication with the specimen receptacle. The positioning of the input aperture enables the light from the light source to be evenly distributed across an exterior surface of a specimen placed within the specimen receptacle.