The present disclosure provides a novel serine protease variant.

Microorganisms for lowering blood ammonia level and composition for protecting neuronal cells containing the same, particularly relates to microbes or a symbiotic pair that has a neuroprotective function by lowering blood ammonia levels or reducing ammonia levels in the body and composition for protecting neuronal cells comprising the microbes. The microorganisms having a neuroprotective function by lowering the blood ammonia level can be selected from the group that include, but not limited to, a Lactobacillus sp. strain and a Streptococcus sp. strain. The ammonia removal strains and the composition have a neuroprotective effect by their excellent ability to remove neurotoxic ammonia, and thus can be widely used as a preventive or therapeutic agent for hyperammonemia and neurological diseases caused thereby.

Genetically modified microorganisms which are resistant to infection by bacteriophages and that retain their kinetic parameters and methods of making the same.

Disclosed are novel bioremediation formulations and inocula for formulation of bioremediation formulations. The formulations of the present disclosure comprise viable microorganisms of the species Paenibacillus xylanexedens, Pseudomonas fluorescens, Bacillus safensis, Streptomyces griseus, Micrococcus luteus, and Bacillus megaterium and can be used to degrade glyphosate residue associated with a substrate contaminated with glyphosate, and thereby remedially treat the substrate. Related methods are also disclosed.

The present invention relates to a novel microorganism capable of metabolizing various carbon sources at high rates. A novel microorganism according to the present invention was observed to grow at a very high rate in a minimal medium/nutrient medium, etc., compared to microorganisms such as Escherichia coli, and shows resistance at a high initial sugar/salt concentrations as well as being able to produce lycopene and 2,3-butanediol through genetic manipulation. Therefore, the novel microorganism can be used in various production fields of high value-added compounds using microorganisms.

The present invention relates to a method of storing a biocatalyst, which biocatalyst is capable of converting acrylonitrile to acrylamide, comprising the steps: (a) providing an aqueous suspension comprising the biocatalyst, which is capable of converting acrylonitrile to acrylamide, which aqueous suspension is an aqueous fermentation broth; (b) sequentially in either order or simultaneously (b) concentrating the aqueous suspension comprising the biocatalyst to a concentration of at least 3% (w/w); and (b2) reducing the temperature of the aqueous suspension comprising the biocatalyst to a temperature of below 8° C., thereby forming a concentrated aqueous suspension; and (c) maintaining the concentrated aqueous suspension of step (b) at a temperature of below 8° C. The invention also relates to a biocatalyst composition obtainable by this method and also the use of the biocatalyst composition in a process of preparing (meth-) acrylamide aqueous solution from (meth-) acrylonitrile. The invention further relates to a method for producing an aqueous (meth-) acrylamide solution comprising the aforementioned storage method and also to a method for producing polyacrylamide comprising the aforementioned storage method.

A method of fixating and stabilizing nitric oxide metabolites within fermented natural substance according to an embodiment of the present disclosure includes adding a fermentative strain to nitrogen-containing natural substance and carrying out fermentation. The fermentation efficiency is maximized by optimizing the fermentation conditions so that the productivity of nitric oxide metabolites is significantly improved. Thus, eating a fermented natural substance in which nitric oxide metabolites are fixated and stabilized by the method of the present invention would be helpful for maintaining the homeostasis of human body, in which nitric oxide synthase is either absent or insufficient, based on vasodilation and activation of a neurotransmitter and immune function as medical efficacy of nitric oxide.

The present invention provides novel Lactococcus lactis lactic acid bacterium strains having improved texturing properties and methods of using the strains for producing food products.

The disclosure provides novel microbial strains, such as Veillonella sp. strains, and compositions comprising the strains that are capable of converting lactate to propionate and acetate. The disclosure also provides compositions comprising the Veillonella sp. strains and lactate producing bacteria, such as Lactobacillus sp. strains and Bifidobacterium sp. strains. The disclosure further provides methods of improving athletic performance, enhancing exercise endurance and reducing inflammation in a subject upon administration of the disclosed strains or compositions.

Provided are novel piperazic acid containing peptide compound stereoisomer, solvate, or pharmaceutically acceptable salt thereof, method of preparing the same, and use thereof. The peptide compound, stereoisomer, solvate, or pharmaceutically acceptable salt thereof has activities of anticancer, anti-metastasis, and growth inhibition of resistant tumors, and thus may be used to prevent or treat various cancers or metastases of cancer.