The invention provides engineered plants that are salt tolerant, methods for making these plants and uses of these plants.

Aspects of the present invention disclose compounds that modulate the aggregation of amyloidogenic proteins or peptides. In some aspects, disclosed compounds modulate the aggregation of disease-associated proteins and natural -amyloid peptides. In a preferred embodiment, the compounds can inhibit natural amyloid aggregation. Pharmaceutical compositions comprising the compounds of the embodiments, and diagnostic and treatment methods for diseases (e.g., amyloidogenic diseases) using the compounds, are also disclosed. In addition, there is provided an integrated bacterial platform for the discovery of rescuers of disease-associated protein misfolding.

In some aspects, the disclosure relates to compositions and methods useful for inhibiting SOD1 expression in cells (e.g., cells of a subject). In some embodiments, the disclosure describes isolated nucleic acids engineered to express an inhibitory nucleic acid targeting endogenous SOD1 and an mRNA encoding a hardened SOD1 protein. In some embodiments, compositions and methods described by the disclosure are useful for treating Amyotrophic Lateral Sclerosis (ALS) in a subject.

Polypeptides with superoxide dismutase activity of bacterial origin are useful in animal feed additives for improvement of animal growth and performance and in improving animal health, particularly animals exposed to environmental or heat stress.

Provided are compositions and methods for introducing proteins into cells. The compositions and methods relate to introducing a foreign protein as an engineered component of a paramyxovirus virus like particle (VLP). The compositions and methods pertain to modified VLPs that contain a contiguous recombinant polypeptide comprising i) all or a segment of a C-terminal domain of a paramyxovirus nucleocapsid protein and ii) a polypeptide sequence of a distinct protein that is an enzyme such as a recombinase.

Provided are preparation method for corn superoxide dismutase, including: S1. corn pre-treatment; S2. enzymatic hydrolysis: S21. transferring corn slurry into rotary screen, and immersing lower half of drum into enzymatic hydrolysis mixed liquid; starting rotary screen, to enable corn material to tumble inside drum while remaining immersed in enzymatic hydrolysis mixed liquid; S22. extracting enzymatic hydrolysis mixed liquid at fixed intervals to undergo centrifugal separation, to remove starch granules and other impurities; S23. pouring centrifuged clear liquid back into rotary screen, and performing enzymatic hydrolysis cyclically; S24. uniformly stirring corn slurry having undergone enzymatic hydrolysis and filtering, collecting filtrate; and S3. extraction and post-treatment.

The present invention relates to recombinant, or synthetic caviar polypeptides and methods for their production. The invention also relates to cosmetic products comprising recombinant or synthetic polypeptides of the invention.