The present invention provides compositions and methods for treating a myopathy. In certain embodiments, the invention provides compositions and methods for treating, improving muscle function, and prolonging survival in a subject with X-linked myotubular myopathy (XLMTM). The present invention provides a method comprising systemic administration of a composition that induces the increased expression of myotubularin in the muscle of a subject. The invention provides sustained regional and global increases in muscle function.

The present invention provides compositions and methods for treating a myopathy. In certain embodiments, the invention provides compositions and methods for treating, improving muscle function, and prolonging survival in a subject with X-linked myotubular myopathy (XLMTM). The present invention provides a method comprising systemic administration of a composition that induces the increased expression of myotubularin in the muscle of a subject. The invention provides sustained regional and global increases in muscle function.

According to the present disclosure, on the basis of all existing mutations, the tenth glycine of a BC-PC-PLC is mutated into aspartic acid, a specific enzyme activity thereof is 83% higher than that of a sequence before the mutation, and protein expression and degumming activity of unit enzyme activity do not change, so as to further reduce manufacturing costs.

According to the present disclosure, on the basis of all existing mutations, the tenth glycine of a BC-PC-PLC is mutated into aspartic acid, a specific enzyme activity thereof is 83% higher than that of a sequence before the mutation, and protein expression and degumming activity of unit enzyme activity do not change, so as to further reduce manufacturing costs.

A method according to an embodiment of the present disclosure is for enhancing disease resistance of a plant against Soybean mosaic virus compared to a non-transformant. The method may include transforming a plant cell of the plant with a recombinant vector containing a gene encoding Glycine max purple acid phosphatase 2.1 (GmPAP2.1) protein from Glycine max to overexpress the gene encoding GmPAP2.1 protein. As the GmPAP2.1 gene from Glycine max of the present invention can modulate disease resistance against Soybean mosaic virus, it is expected to be applied for development of new cultivars with enhanced resistance to Soybean mosaic virus to thereby increase soybean productivity.

A method according to an embodiment of the present disclosure is for enhancing disease resistance of a plant against Soybean mosaic virus compared to a non-transformant. The method may include transforming a plant cell of the plant with a recombinant vector containing a gene encoding Glycine max purple acid phosphatase 2.1 (GmPAP2.1) protein from Glycine max to overexpress the gene encoding GmPAP2.1 protein. As the GmPAP2.1 gene from Glycine max of the present invention can modulate disease resistance against Soybean mosaic virus, it is expected to be applied for development of new cultivars with enhanced resistance to Soybean mosaic virus to thereby increase soybean productivity.

Disclosed are genetically engineered microbial cells for the production of oligosaccharides comprising a galactose-β1,4-glucose moiety at their reducing end, wherein said microbial cells are able to produce said oligosaccharides in the absence of exogenously added lactose, and a method of producing said oligosaccharides using said microbial cells.

Disclosed are genetically engineered microbial cells for the production of oligosaccharides comprising a galactose-β1,4-glucose moiety at their reducing end, wherein said microbial cells are able to produce said oligosaccharides in the absence of exogenously added lactose, and a method of producing said oligosaccharides using said microbial cells.

The present invention provides a method for preventing or treating a liver disease selected from the group consisting of non-alcoholic fatty liver, non-alcoholic steatohepatitis and hepatic fibrosis comprising administrating at least one selected from the group consisting of an Ssu72 peptide, a polynucleotide encoding the Ssu72 peptide, and an expression vector comprising the polynucleotide.

Provided is Lactobacillus paracasei TCI727, deposited in the Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH (DSMZ) with a deposit number of DSM 33756. A method for improving calcium absorption of a subject in need thereof by using the Lactobacillus paracasei TCI727 or metabolites thereof is also provided. The method includes administering to the subject an effective amount of a composition comprising the Lactobacillus paracasei TCI727 or the metabolites thereof.