Patent classifications
C
C12
C12N
2502/00
C12N2502/09
C12N2502/092
C12N2502/092
METHOD FOR PRODUCING INNER EAR ORGANOIDS USING RETINOIC ACID AND INNER EAR ORGANOIDS PRODUCED BY THE METHOD
20250207104
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2025-06-26
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The present disclosure relates to a method for producing an inner ear organoid with improved differentiation efficiency of hair cells. The inventors of the present disclosure have confirmed that when retinoic acid is treated at the stage of formation of the lamina propria during the production of an inner ear organoid, the differentiation potential of hair cells is excellent. Therefore, it is expected that the inner ear organoid produced according to the production method of the present disclosure can be advantageously utilized in hearing loss disease modeling, drug screening and regenerative medicine.