The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize chiral compounds.

A grille lighting system includes a light emitting lamp that includes one or more walls defining an inner space isolated from outside, a light emitting material disposed in the inner space and configured to emit light when the light emitting material contacts air, and a shutter disposed on the one or more walls, wherein the shutter is configured to be opened to allow introduction of outside air to the inner space from outside and further configured to be closed to block introduction of outside air to the inner space. The system further includes a controller configured to control operation of the shutter and cause the shutter to be opened and closed such that when the shutter is opened, the outside air is introduced to contact the light emitting material, which causes the light emitting material to emit light.

The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize chiral compounds.

The present invention relates to methods for synthesizing mixed disulfide conjugates of thienopyridine compounds with a genetically engineered variant of cytochrome P450 BM3 or CYP102A1 as a catalyst, and belongs to the field of chemical synthesis.

Provided herein, inter alia, is a modular-functional technology for the expression of a functional heterologous polyketide synthases (PKS) system in a photosynthetic cyanobacteria.

Microorganisms and bioprocesses are provided that convert gaseous C1 containing substrates, such as syngas, producer gas, and renewable H.sub.2 combined with CO.sub.2, into nutritional and other useful bioproducts.

Provided is a process for synthesizing a functionalized cyclic dithiocarbamate.

A grille lighting system includes a light emitting lamp that includes one or more walls defining an inner space isolated from outside, a light emitting material disposed in the inner space and configured to emit light when the light emitting material contacts air, and a shutter disposed on the one or more walls, wherein the shutter is configured to be opened to allow introduction of outside air to the inner space from outside and further configured to be closed to block introduction of outside air to the inner space. The system further includes a controller configured to control operation of the shutter and cause the shutter to be opened and closed such that when the shutter is opened, the outside air is introduced to contact the light emitting material, which causes the light emitting material to emit light.

The invention provides a genetically modified bacterium for production of thiamine; where the bacterium is characterized by a transgene encoding a thiamine monophosphate phosphatase (TMP phosphatase having EC 3.1.3.-) as well as transgenes encoding polypeptides that catalyze steps in the thiamine pathway. The genetically modified bacterium is characterized by enhanced synthesis and release of thiamine into the extracellular environment. The invention further provides a method for producing thiamine using the genetically modified bacterium of the invention; as well as the use of the genetically modified bacterium for extracellular thiamine production.

Microorganisms and bioprocesses are provided that convert gaseous C1 containing substrates, such as syngas, producer gas, and renewable H.sub.2 combined with CO.sub.2, into nutritional and other useful bioproducts.