The invention provides methods of identifying the gene expression profile of a cell type present within a population of cells using single cell expression data by a residual minimization process. The methods of the invention can be used to infer the genes expressed by a rare cell type that can be difficult to measure experimentally due to its low abundance in an organism or sample of interest. The methods described herein can additionally be used to predicting the gene expression profile of a population of cells using single cell expression patterns as well as methods of quantitating the composition of a population.

The invention provides methods of identifying the gene expression profile of a cell type present within a population of cells using single cell expression data by a residual minimization process. The methods of the invention can be used to infer the genes expressed by a rare cell type that can be difficult to measure experimentally due to its low abundance in an organism or sample of interest. The methods described herein can additionally be used to predicting the gene expression profile of a population of cells using single cell expression patterns as well as methods of quantitating the composition of a population.

Methods, and compositions are provided for high-efficiency hybrid capture.

Methods, and compositions are provided for high-efficiency hybrid capture.

A method of forming a metadatabase of minimal epitope profiles including: performing antibody activity profiling from an immunoglobulin fraction of a plurality of samples to form a data set of peptide profiles for each sample, comparing peptide profiles across different samples, assigning a diagnosis or disorder to differentially expressed meta-profiles, constructing a meta-database containing minimal epitope clusters, constructing a database of peptide frequencies, aligning peptides to define the sequence of minimal epitope, verifying the minimal epitope by harboring a connected identifier, providing an enriched affinity sample, and providing a source data for metadatabase a database underlying it.

A method of forming a metadatabase of minimal epitope profiles including: performing antibody activity profiling from an immunoglobulin fraction of a plurality of samples to form a data set of peptide profiles for each sample, comparing peptide profiles across different samples, assigning a diagnosis or disorder to differentially expressed meta-profiles, constructing a meta-database containing minimal epitope clusters, constructing a database of peptide frequencies, aligning peptides to define the sequence of minimal epitope, verifying the minimal epitope by harboring a connected identifier, providing an enriched affinity sample, and providing a source data for metadatabase a database underlying it.