The present invention relates to the strain of Lactobacillus plantarum NCIMB 43029, the strain of Lactobacillus acidophilus NCIMB 43030, a composition with both antibacterial and re-epithelializing action which includes Lactobacillus plantarum and Lactobacillus acidophilus and optionally Streptococcus thermophilus and/or Bacillus amyloliquefaciens intended to be used as a medicament for the re-epithelialisation of lesions or wounds, a bandage comprising said composition and kits comprising such a composition.

Provided herein are dairy-like analogue compositions and the methods of making the same using one or more recombinant proteins.

The present invention relates to a method of producing a fermented milk product comprising adding lactic acid bacteria to milk, wherein the bacteria comprise Lactobacillus casei and at least one further strain of lactic acid bacteria of a species other than Lactobacillus casei, wherein the further strain has a deficiency in lactose metabolism but is capable of metabolizing one or several carbohydrates other than lactose present in the milk.

Disclosed in the present invention is a pharmaceutical composition, comprising: 1) a reagent for reducing bonding between an Fc receptor and an endogenous serum antibody, wherein the reagent comprises an immunoglobulin degrading enzyme or endo-glycosidase; and 2) a viral vector drug, wherein the viral vector drug is selected from an oncolytic virus and a viral vaccine. The pharmaceutical composition allows individual administration of the viral vector drug and the reagent. Further disclosed in the present invention are an application of the pharmaceutical composition in the preparation of a drug for treating or preventing disasters, and a method for applying the pharmaceutical composition to a subject to treat or prevent cancers or infections.

Provided is a composition comprising a novel strain, a lysate thereof or a culture product thereof, which can demonstrate excellent effects in strengthening skin barrier, moisturizing skin, enhancing skin elasticity or anti-aging, and can be used for a cosmetic composition or health functional food.

The present invention provides a Lactococcus lactis subsp. lactis A32, derived product and use thereof, the present invention falls in the technical field of microorganisms. In the present invention, the Lactococcus lactis subsp. lactis A32 is obtainable by compound mutation on the basis of the original strain L. lactis lxl. Experiments showed that, compared with nisin titre of the original strain L. lactis lxl, the Lactococcus lactis subsp. lactis A32 has high nisin yield, and the nisin titre has been improved for 3˜4 times (over 5066.58 IU/mL); in the meanwhile, the growth curve of the Lactococcus lactis subsp. lactis A32 is slightly longer than the original strain L. lactis lxl and biomass peaks of them are basically consistent. The present invention has laid a foundation for large scale production of nisin.

The present invention provides for recombinant Endo-S mutants that exhibit reduced hydrolysis activity and increased transglycosylation activity for the synthesis of glycoproteins wherein a desired sialylated oxazoline or synthetic oligosaccharide oxazoline is added to a core fucosylated or nonfucosylated GlcNAc-protein acceptor. Such recombinant Endo-S mutants are useful for efficient glycosylation remodeling of IgG1-Fc domain to provide different antibody glycoforms carrying structurally well-defined Fc N-glycans.

Methods to edit genes by administering a chimeric nuclease to a cell or organism without the use of a viral vector.

Provided is a mutant of an immunoglobulin degrading enzyme IdeE. The immunoglobulin degrading enzyme IdeE includes an amino acid sequence as shown in SEQ ID NO: 2 in the sequence listing. The mutant is obtained by means of replacing at least one or more of the positions 8, 10, 24, 59, 97, and 280 of the amino acid sequence. The function of the mutant includes at least the function of the immunoglobulin degrading enzyme IdeE. The activity and thermal stability of the provided mutant of the immunoglobulin degrading enzyme are higher than those of a wild-type IdeE.

Provided is a composition comprising a novel strain, a lysate thereof or a culture product thereof, which can demonstrate excellent effects in strengthening skin barrier, moisturizing skin, enhancing skin elasticity or anti-aging, and can be used for a cosmetic composition or health functional food.