The present invention provides a compound represented by chemical formula 1, an optical isomer thereof or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition for preventing or treating Wnt/?-catenin signaling-associated diseases, comprising same.

Disclosed are microbial compositions having unique combinations of microbial species which are used in plant material recycling and retting. Also disclosed microbial inoculants which contains such a microbial composition, water, and an optional carbon source. The microbial compositions and microbial inoculants are particularly useful in recycling high lignin-content plant material. Methods of making and methods of using the microbial compositions and the microbial inoculants are also described.

Provided are a novel streptomyces filamentosus strain with improved daptomycin productivity, and a method for producing daptomycin using the same.

Streptomyces badius SP6C4 strain has an antimicrobial activity against an insect pathogen or a strawberry fungal disease pathogen isolated from strawberry pollen. The growth of an insect pathogen and a strawberry fungal disease pathogen is suppressed by Streptomyces badius SP6C4 strain isolated from strawberry pollen. Streptomyces badius SP6C4 strain can be used as an environmentally friendly biological agrochemical which is free of any environmental contamination yielded as a side effect of an agrochemical or any human toxicity caused by residual agrochemicals, and, by having an excellent effect of controlling American foul brood, chalk brood, and strawberry flower mold disease, it can be very advantageously used in terms of an industrial use.

Provided herein are biofilm inhibitors obtained from marine microbial derived natural product extracts from Streptomyces gandocaensis, resulting in biofilm inhibitors, cahuitamycins. Also provided are mutant S. gandocaensis, methods of inhibiting biofilm formation, methods of producing, or increasing the production of, cahuitamycins, methods for synthesizing cahuitamycins, and methods of purifying cahuitamycins.

The present disclosure provides compositions comprising novel endophytes capable of promoting germination endophytes that have a symbiotic relationship with plants. The present disclosure further provides methods of improving seed vitality, biotic and abiotic stress resistance, plant health and yield under both stressed and unstressed environmental conditions, comprising inoculating a seed with the novel endophyte strains and cultivating a plant therefrom.

A method for controlling a plant disease according to an embodiment includes treating a plant part, a seed, or a soil with a composition including at least one amino acid selected from the group consisting of glutamic acid, proline, tryptophan, and a combination thereof as an effective component. A method for promoting growth of an effective microorganism or controlling a plant disease uses prebiotics. As the amino acids have an effect of significantly promoting the growth of effective microorganism and having sustained maintenance of the effective microorganism at the same time and can reduce the incidence rate of plant disease, they can enhance the usefulness of eco-friendly microbial strains for disease control and be advantageously used as a substitute for chemical control agents.

A method for producing L-isoleucine at a higher yield by fermentation includes the step of using a genetic engineering method to obtain a genetically engineered strain. The genetically engineered strain has a threonine deaminase gene substantially releasing the inhibition of L-isoleucine and/or an acetylated hydroxy acid synthetase III gene substantially releasing the inhibition of L-isoleucine; and performing fermentation culture on the genetically engineered strain, adding diketobutyric acid or a raw material capable of being converted into diketobutyric acid in a culture process, and separating L-isoleucine from a culture after the end of culturing. Further provided is a genetically engineered strain for realizing high yield of L-isoleucine.

The present invention relates to the field of biocontrol of plant pathogenic fungi, particularly to bacterial strains effective in treating and/or preventing plant diseases associated with phytopathogenic fungi and/or oomycetes; preparations, lysates and extracts thereof, compositions comprising same and use thereof.

Disclosed is a genetically modified host organism for expressing an anthracyclinone analogue. The genetically modified host organism comprises (i) synthetic nucleic acids; (ii) a biosynthetic pathway encoded by the synthetic nucleic acids, the (ii) biosynthetic pathway comprising a ketosynthase alpha, a ketosynthase beta/chain-length factor, an acyl carrier protein, a 3-oxoacyl-ACP synthase, a propionyl-CoA acyltransferase, a 9-ketoreductase, an aromatase/cyclase, and a second/third-ring cyclase; and (iii) a promoter positioned upstream of and operatively associated with the (ii) biosynthetic pathway. A method and corresponding synthetic nucleic acids are also disclosed.