Provided herein are Streptomyces isolates, designated MH71 and MH243, cultures thereof, and compositions comprising the same. Also provided are uses of the isolates, cultures and compositions, for example, for treating and preventing infections and diseases caused by or associated with plant pathogen infections, reducing the susceptibility of plants to diseases caused by or associated with plant pathogen infections, and for inhibiting or reducing the growth of pathogens on plants.

The present invention provides for a cyclopropane compound having the following chemical formula:

##STR00001##

wherein α is —H or —COOR, wherein R is —H or an alkyl group, such as —CH.sub.3, —CH.sub.2CH.sub.3, —(CH.sub.2).sub.2—CH.sub.3, —(CH.sub.2).sub.3—CH.sub.3, or —C(CH.sub.3).sub.3; β is each independently

##STR00002##

wherein at least one β is

##STR00003##

and, n is an integer from 3 to 11. A fuel composition comprising the cyclopropane compound thereof and a fuel additive. The present invention also provides for a system or genetically modified host cell capable of producing the cyclopropane compound, and a method for producing the cyclopropane compound.

Methods for selecting a microbe for co-formulation with a carrier are provided. In some examples, the methods include identifying a microbe that comprises one or more dipicolinic acid (DPA) synthase genes, a microbe that expresses one or more DPA synthase proteins, and/or a microbe that produces DPA; and selecting the microbe for co-formulation with a carrier. The methods optionally include co-formulating the selected microbe with the carrier. In some examples, the methods include detecting one or more DPA synthase genes or one or more DpaA and/or DpaB proteins in a microbe. In other examples, the methods include detecting DPA in a microbe or medium containing a microbe, for example, utilizing a fluorescence assay. Microbial compositions including one or more microbes that comprise one or more DPA synthase genes, express one or more DPA synthase proteins and/or produce DPA are also provided.

Anticancer compounds of general formula I

##STR00001## wherein R.sub.1 to R.sub.4 take various meanings, for use in the treatment of cancer. A novel Labrenzia sp. strain named PHM005 with Accession Deposit Number CECT-9225, a method of producing compounds of the invention and analogues thereof by using the PHM005 strain and the Lab gene cluster codifying the biosynthesis of pederin-like and onnamide-like compounds are also provided.

The process of making a biocomposite material utilize a bacterial species and a fungal species in an agricultural feedstock composed of a substrate of non-nutrient discrete particles and a nutrient material wherein the bacterial species imparts mechanical properties to the biocomposite material and the fungal species binds the biocomposite material. Both bacterium and fungus can be genetically engineered to produce desired properties within the microbial communities.

The present invention relates to the field of sustainable agriculture. Specifically, the invention provides microbial compositions and methods useful for the production of crop plants. In particular, the compositions and methods disclosed herein are useful for enhancing plant growth.

The disclosure relates to a systemic platform for developing soil-borne plant pathogen inhibiting microbial consortia. The platform utilizes multivariate computer modelling and multidimensional ecological function balancing (MEFB) nodal analysis to develop microbial consortia, consortia, and inoculants. The disclosure further relates to a prescriptive biocontrol system that will enable farmers to have site-specific agricultural biologics developed for their specific site and crop of interest.

In some aspects, the disclosure relates to production of bacterial secondary metabolites. In some embodiments, the disclosure relates to a genetically engineered Streptomyces J1074 bacterium, wherein the bacterium comprises a nucleic acid having a modification to at least one global regulator gene.

A peptide cyclase that has the amino acid sequence represented by SEQ ID NO: 1 or a mutated sequence thereof, or a peptide cyclase that has an amino acid sequence encoded by a base sequence encoding the amino acid sequence represented by SEQ ID NO: 1 or a mutated sequence thereof; DNA encoding the peptide cyclase; a method for producing the peptide cyclase; and a method for producing a cyclic peptide using the peptide cyclase.

Disclosed is a genetically modified host organism for expressing an anthracyclinone analogue. The genetically modified host organism comprises (i) synthetic nucleic acids; (ii) a biosynthetic pathway encoded by the synthetic nucleic acids, the (ii) biosynthetic pathway comprising a ketosynthase alpha, a ketosynthase beta/chain-length factor, an acyl carrier protein, a 3-oxoacyl-ACP synthase, a propionyl-CoA acyltransferase, a 9-ketoreductase, an aromatase/cyclase, and a second/third-ring cyclase; and (iii) a promoter positioned upstream of and operatively associated with the (ii) biosynthetic pathway. A method and corresponding synthetic nucleic acids are also disclosed.