Patent classifications
C12Y101/01049
MULTI-SUBSTRATE METABOLISM FOR IMPROVING BIOMASS AND LIPID PRODUCTION
The present application relates to methods to improve biomass or lipid production in a microorganism from one or more fatty acid and one or more simple carbon co-substrates. Produced lipids may include unsaturated C.sub.6-C.sub.24 fatty acids, alcohols, aldehydes, and acetates which may be useful as final products or precursors to insect pheromones, fragrances, flavors, and polymer intermediates. The application further relates to recombinant microorganisms modified for improved production of biomass or lipid, or improved lipid selectivity. Also provided are methods of producing one or more lipid using the recombinant microorganisms, as well as compositions comprising the recombinant microorganisms and/or optionally one or more of the product lipid.
BIOSYNTHESIS OF BENZYLISOQUINOLINE ALKALOIDS AND BENZYLISOQUINOLINE ALKALOID PRECURSORS
Recombinant microorganisms, plants, and plant cells are disclosed that have been engineered to have reduced levels or activity of one or more alcohol dehydrogenases or aldehyde reductases thereby increasing the production of benzylisoquinoline alkaloids and/or benzylisoquinoline alkaloid precursors.
Increased biosynthesis of benzylisoquinoline alkaloids and benzylisoquinoline alkaloid precursors in a recombinant host cell
Recombinant microorganisms, plants, and plant cells are disclosed that have been engineered to have reduced levels or activity of one or more alcohol dehydrogenases or aldehyde reductases thereby increasing the production of benzylisoquinoline alkaloids and/or benzylisoquinoline alkaloid precursors.
Engineered Biosynthetic Pathways for Production of Histamine by Fermentation
The present disclosure describes the engineering of microbial cells for fermentative production of histamine and provides novel engineered microbial cells and cultures, as well as related histamine production methods.
Preparation of multi-hapten mutant G6PDH conjugates and their use for detection of multiple analytes
The present invention relates to multi-hapten mutant G6PDH conjugates, methods of their preparation and their use for detection of multiple analytes. The compositions of the invention comprise different types of haptens (molecules) require to be immobilized into the G6PDH to make one multi-hapten-G6PDH conjugate. Both thiol and amine functional groups on G6PDH are utilized for immobilization of different haptens.
HOMEOSTATIC REGULATION OF L-DOPA BIOSYNTHESIS
Disclosed herein are methods and compositions for the production of L-3,4-dihydroxyphenylalanine from a bacteria.
Artificial forisome body with SEO-F fusion proteins, plant or yeast cells comprising vectors which code for these proteins, as well as vectors which code for SEO-F fusion proteins
The invention relates to artificial forisome bodies including a fusion protein of at least one SEO-F protein or an at least 50-amino acid portion thereof, and at least one additional protein or peptide, with the exception of GFP and the Venus protein, wherein in an embodiment the forisome body further includes an unfused SEO-F protein or a form of the protein having C-terminal deletions of up to 45 amino acids and/or N-terminal deletions of up to 13 amino acids, wherein the unfused SEO-F protein is selected from proteins having the property of being capable of forming homomeric forisome bodies in the absence of additional SEO-F proteins.
ARTIFICIAL FORISOME BODIES WITH SEO-F FUSION PROTEINS, PLANT OR YEAST CELLS WITH VECTORS FOR ENCODING THESE PROTEINS AND VECTORS FOR ENCODING SEO-F FUSION PROTEINS
Artificial forisome bodies include a fusion protein of at least one SEO-F protein or an at least 50-amino acid portion of an SEO-F protein, and at least one additional protein or peptide, with the exception of GFP and the Venus protein. The additional protein or peptide has a mass of at most 30 kDa, or the forisome body further includes an unfused SEO-F protein or a form of the protein having C-terminal deletions of up to 45 amino acids and/or N-terminal deletions of up to 13 amino acids, in which the unfused SEO-F protein is a protein capable of forming homomeric forisome bodies in the absence of additional SEO-F proteins.
Bacterial cytochrome P450 protein variant and method of reducing concentration of fluorinated methane in sample using the same
Provided is a recombinant microorganism including an exogenous gene encoding a bacterial cytochrome P450 protein or a variant thereof, a composition including the recombinant P450 protein or the variant thereof, which is used for removing CH.sub.nF.sub.4-n (n is an integer of 0 to 3) in a sample, and a method of reducing a concentration of CH.sub.nF.sub.4-n in the sample.
RECOMBINANT MICROORGANISMS CAPABLE OF CARBON FIXATION
A microorganism which is genetically modified so that it produces a first essential biomass precursor by metabolizing CO.sub.2 using a recombinant carbon fixation enzyme is disclosed. The microorganism produces a second biomass precursor by metabolizing an organic carbon source and not by metabolizing CO.sub.2. The microorganism does not use the organic carbon source for producing the first essential biomass precursor.