The invention relates to a mineral wool product comprising mineral fibers bonded by a cured binder wherein the binder in its uncured state comprises at least one protein and at least one enzyme.

The invention relates to an aqueous binder composition for mineral fibers comprising at least one hydrocolloid.

The disclosure relates to compositions and methods for treatment of diseases associated with aberrant lysosomal function, such as fronto-temporal dementia (FTD). The disclosure also provides expression constructs comprising a transgene encoding progranulin or a portion thereof. The disclosure provides methods of treating FTD by administering such expression constructs to a subject in need thereof.

The present disclosure provides a method for chemoselective modification of a cell surface molecule on a target cell. A subject method includes contacting a target cell comprising cell surface molecule comprising a thiol, an amine, or an imidazole with a biomolecule comprising a reactive moiety, wherein the reactive moiety is generated by reaction of a biomolecule (e.g., an antibody) comprising a phenol moiety or a catechol with an enzyme capable of oxidizing the phenol or the catechol moiety. The contacting is carried out under conditions sufficient for conjugation of the cell surface molecule to the biomolecule, thereby producing a modified cell. The present disclosure provides kits for carrying out a subject method. The present disclosure also provides modified cells and methods for using same.

Disclosed are processes and methods for production of pigment compounds, such as melanin, using engineered microbial systems and chemical modifications to intermediate compounds. One process involves producing a first intermediate (e.g., an amino acid like tyrosine) and a second intermediate (e.g., an enzyme like tyrosinase) within a microbial cell, exporting the intermediates to an extracellular medium, and enabling their reaction outside the cell to form the pigment compound. The microbial cell is genetically engineered to enhance production and export of intermediates, prevent reuptake, and optimize enzyme activity post-export. Additional intermediates or capping agents are introduced to modulate pigment properties, such as color, molecular weight, and solubility. The process may be applied to produce various pigments, including pheomelanin and violacein, and is scalable for industrial applications in textiles, cosmetics, and carbon sequestration. The system minimizes cellular toxicity, simplifies purification, and allows for tailored pigment production.

A method for forming an aqueous graphene-peptide dispersion. Graphene, a peptide, water and a tyrosinase enzyme are mixed. The resulting suspension is sonicated or vortexed until an aqueous graphene-peptide dispersion forms.