Provided are methods for treating cancer in a patient by administering at least one antibiotic selected from the group consisting of clofazimine, rifabutin and clarithromycin, in combination with an aryladamantane compound. In an embodiment, the aryladamantane compound is [3-(4-chlorophenyl)-adamantane-1-carboxylic acid (pyridin-4-ylmethyl)amide], or a pharmaceutically acceptable salt thereof.

Oral formulations comprising a compound of Formula (I) and a chelating agent are provided, wherein compounds of Formula (I) have the structure: ##STR00001##
wherein, W, X, Y, Z, R.sup.a, R.sup.c, and each R.sup.g are as defined herein. Also provided are methods of preparation, methods of use, and specific dosage forms.

This disclosure relates to N4-hydroxycytidine derivatives, compositions, and methods related thereto. In certain embodiments, the disclosure relates to the treatment and prophylaxis of viral infections.

Minimally invasive treatment methods for benign prostatic hyperplasia (BPH) tissue. A system includes a sustained release formulation comprising a cytostatic or cytotoxic drug, and an applicator or delivery system for local delivery of a composition comprising or consisting essentially of the sustained release formulation to the prostate. The applicator containing the composition is characterized by a KIR value of between 40 and 400 Centipoise per unit area.

A method is provided for preventing and/or treating heart failure in a subject in need thereof by administering to the subject a therapeutically effective amount of polydextrose. The method may also include the use of polydextrose for preventing cardiac remodeling and/or ventricle dilatation and/or for preventing systolic dysfunction, as well as preventing an increase in bacterial translocation to heart tissue in a subject who suffered from a myocardial infarction.

Disclosed are methods and compositions related to methods of treating, ameliorating, mitigating, slowing, arresting, preventing or reversing various diseases and conditions, including age-related obesity, age-related increases in blood lipid levels, age-related decreases in insulin sensitivity, age-related decreases in memory function, and age-related changes in eye function such as macular degeneration. The methods comprise administering nicotinamide mononucleotide (NMN) to a subject. In some embodiments, the administration can be oral administration. Also disclosed are pharmaceutical compositions comprising NMN.

Provided herein are safened herbicidal compositions for use in Brassica species susceptible to injury by halauxifen comprising (a) a herbicidally effective amount of halauxifen or an agriculturally acceptable salt or ester of thereof, and (b) one or more of (i) a herbicide[s], capable of safening the halauxifen to the Brassica species, or an agriculturally acceptable salt or ester thereof, or (ii) a herbicide safener, capable of safening the halauxifen to the Brassica species, or an agriculturally acceptable salt or ester thereof.

Provided herein are safened herbicidal compositions for use in Brassica species susceptible to injury by halauxifen comprising (a) a herbicidally effective amount of halauxifen or an agriculturally acceptable salt or ester of thereof, and (b) one or more of (i) a herbicide[s], capable of safening the halauxifen to the Brassica species, or an agriculturally acceptable salt or ester thereof, or (ii) a herbicide safener, capable of safening the halauxifen to the Brassica species, or an agriculturally acceptable salt or ester thereof.

The present invention relates to novel 5′-substituted nucleoside compounds, pharmaceutical compositions comprising the compounds, and methods of using the compounds to treat cancer, more particularly for the treatment of cancer, in particular glioblastomas, melanoma, sarcomas, gastric cancer, pancreatic cancer, cholangiocarcinoma, bladder cancer, breast cancer, non-small cell lung cancer, leukemias including acute myeloid leukemia, and lymphomas.

The present invention relates to new morpholinyl anthracycline derivatives which have cytotoxic activity and are useful in treating diseases such as cancer, cellular proliferation disorders and viral infections. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising them and methods of treating diseases utilizing such compounds or the pharmaceutical compositions containing them.