A vaginal device configured to be inserted in a vagina of a user, the vaginal device comprising: a body comprising at least two electrodes configured to measure a fertility-related parameter of the user; a power source configured to provide power to the device; and an electrical system operably connected to the power source, the electrical system operably connected to one or more of the electrodes, the electrical system configured to switch one or more of the electrodes between charging and measuring functions.

An electronic system for determining a fertility phase of a female human comprises a wearable device (1) that includes a first sensor system (101), configured to determine heart rate and heart rate variability of the female human, and a second sensor system (102), configured to determine acceleration of the female human. The electronic system further comprises a processor (13, 30), configured to detect during menstrual cycles sleep phases with resting pulse, using the heart rate variability and the acceleration, to determine a change in the resting pulse during a menstrual cycle using the heart rate, and to determine the fertility phase using a time of the change in the resting pulse. The processor for determining the fertility phase is implemented in the wearable device (1), in a mobile communication device (4), and/or in a cloud-based computer system (3).

An electronic system for detecting events related to a pregnancy of a female human, such as ovulation, conception, and miscarriage, comprises a wearable device (1) with a sensor system (100) worn in contact with the skin for measuring one or more physiological parameters. A processor (13, 30, 40) is configured to receive a user entry indicating a time of actual menses, and to determine time windows, for analyzing physiological parameters of the female human, using the time of actual menses. The processor is further configured to detect the pregnancy related events by comparing the physiological parameters, determined and recorded for a first time window, with those determined and recorded for a second time window, to indicate the pregnancy related events when defined detection criteria are met, and to use the user input for pregnancy related events to optimize the detection of these events with machine learning trained algorithms.

A non-invasive and accurate vagina evaluation device and uterine evaluation devices are provided that measure the receptivity (uterine implantation capacity) of the mother's body to a fertilized egg implanting itself into the uterus. A first vagina evaluation device includes: a main body stretchable and expandable after insertion into a vagina, followed by air injection thereinto; four electrodes brought into contact with the vagina wall as the main body expands and stretches; and fixation means configured to fix the interval of arrangement of the electrodes. Second and third uterine evaluation device include: a flexible and rod-shaped main body for insertion into a uterine cavity; and four or two impedance electrodes arranged with a predetermined interval therebetween in an insertion direction of the main body and brought into contact with an endometrium of the uterine cavity to measure a uterine endometrial impedance generated between the endometrium and each of the electrodes.

The disclosed invention provides a sensing device capable of concentrating a fluid sample with respect to a target analyte and a reference analyte, and measuring the target analyte and reference analyte in the concentrated sample. The invention includes a concentrator that may include a selectively permeable membrane, or a gel having an increasing density gradient. In another embodiment, the invention includes an air or gas gap between a fluid transport channel and the concentrator. In another embodiment, the sensing device includes a driver for electronically moving a fluid sample through the channel and membrane to cause concentration. In some embodiments, the invention may also determine the change in molarity of the fluid sample with respect to the target analyte, as the sample is concentrated by the device.

The disclosed invention provides a fluid sensing device and method capable of collecting a fluid sample, concentrating the sample with respect to one or more target analytes, and measuring the target analyte(s) in the concentrated sample. The invention is also capable of determining the change in molarity of the fluid sample with respect to the target analyte(s), as the sample is concentrated by the device. The invention further includes a method for using a fluid sensing device to concentrate a fluid sample with respect to one or more target analytes. The disclosed method further includes the ability to correlate the measured target analyte concentration to a physiological condition of a device wearer, or of a fluid source.

An electronic system for non-invasive monitoring of estrogen of a female human comprises a wearable device (1) and a processor (13, 30, 40). The wearable device (1) includes a first sensor system (101) configured to be worn in contact with the skin of the female human and to determine a level of perfusion of the female human. The processor (13, 30, 40) is configured to receive and store the level of perfusion of the female human from the first sensor system (101) for a respective point in time. The processor (13, 30, 40) is further configured to determine a change in the level of perfusion of the female human, using the levels of perfusion of the female human stored for a plurality of respective points in time. Furthermore, the processor (13, 30, 40) is configured to detect a change in estrogen level of the female human based on the change in the level of perfusion of the female human.

A system and method for determining a user's physical condition such as a hormonal level are provided. The system includes a portable or wearable device that measures multiple biomarkers, such as basal body temperature, saliva salinity, saliva pH, sweat ions, skin thickness, vitamin levels or breath carbon dioxide. The system determines the physical condition, such as the fertility level of the user based on comparing the measured biomarkers with data models. The determined physical condition, such as the fertility level, is communicated to allow the user to know their status.

The present invention relates to an implantable sensor configured to be implanted within the body of the subject and being configured to measure impedance within a body tissue of the subject resulting from an electrical current flowing through the body tissue, wherein the body tissue is sub-dermal or subcutaneous tissue of the subject. One pair of injection electrodes is configured for injection of electrical current into the body tissue and one pair of sensing electrodes is configured to detect the resulting voltage. A detector is operatively connected to the sensing electrodes and is configured to receive the voltage detected by the sensing electrodes, wherein the detector is configured to measure the impedance of the body tissue based on the voltage detected by the pair of sensing electrodes. A microcontroller is operatively connected to the detector and is configured to receive impedance signals from the detector and to provide control signals to the current signal output circuit and a powering and communication circuit including a coil configured to be powered by an electromagnetic field produced by an external coil.

A non-invasive and accurate vagina evaluation device and uterine evaluation devices are provided that measure the receptivity (uterine implantation capacity) of the mother's body to a fertilized egg implanting itself into the uterus. A first vagina evaluation device includes: a main body stretchable and expandable after insertion into a vagina, followed by air injection thereinto; four electrodes brought into contact with the vagina wall as the main body expands and stretches; and fixation means configured to fix the interval of arrangement of the electrodes. Second and third uterine evaluation device include: a flexible and rod-shaped main body for insertion into a uterine cavity; and four or two impedance electrodes arranged with a predetermined interval therebetween in an insertion direction of the main body and brought into contact with an endometrium of the uterine cavity to measure a uterine endometrial impedance generated between the endometrium and each of the electrodes.