The invention provides a system for treating an occlusion within a body lumen. The system may comprise an insulated outer sheath; an elongated conductive tube, wherein the insulated outer sheath is circumferentially mounted around the elongated conductive tube; and an insulated wire having a helically coiled portion at a distal end of the insulated wire. The coiled portion includes an exposed distal tip, and a distal portion of the elongated conductive tube is circumferentially mounted around the distal coiled portion of the insulated wire. When a voltage is applied across the insulated wire and the elongated conductive tube, a current is configured to flow from the exposed distal tip of the insulated wire to the elongated conductive tube to generate a plurality of cavitation bubbles. In an alternate embodiment, an elongated central electrode is used in place of the conductive tube.

A medical system includes a sheath and an acoustic reflective element that is capable of amplifying acoustic energy. Methods of using a medical system are also provided herein.

A catheter assembly includes a catheter comprising a flexible elongated member including a distal portion that includes a tubular body defining an inner lumen and a plurality of body apertures that extend through a sidewall of the tubular body into the inner lumen, and a plurality of primary electrodes positioned along the tubular body. The catheter assembly includes a wire defining at least one secondary electrode, the wire being configured to be slidably moved through the inner lumen of the tubular body, where the wire and the plurality of primary electrodes are configured to electrically couple to an energy source that delivers an electrical pulse to a fluid in contact with the plurality of primary electrodes and the at least one secondary electrode to cause the fluid to undergo cavitation to generate a pressure pulse wave within the fluid.

A medical device catheter comprises a cavitation bubble chamber configured to contain a cavitation solution, and at least two electrodes positioned within the cavitation bubble chamber to be in contact with the cavitation solution and to form an electrode gap. A proximal end of the medical device catheter is adapted to remain outside the body of the patient during use of the catheter, and a first lumen is in fluid communication with the cavitation bubble chamber and the proximal end, configured to deliver the cavitation solution from the proximal end of the medical device catheter to the cavitation bubble chamber.

In some examples, a catheter includes an elongated member including at least one balloon connected to the elongated member, the at least one balloon being configured to inflate to an expanded state. In the expanded state, the at least one balloon forms at least a portion of a cavity with a wall of a vessel of the patient. The catheter including at least one electrode carried by the elongated member and having at least one surface exposed to the cavity formed by the at least one balloon. The electrode is configured to connect to an energy source that is configured to deliver, via the electrode, an electrical signal to a fluid contained in the cavity and in contact with the electrode to cause the fluid to undergo cavitation to generate a pressure pulse wave within the fluid.

Disclosed herein are medical systems and methods for ultrasonic decomposition of intraluminal clots. A medical system can include a stylet configured to insert into a lumen of a catheter. The stylet can include one or more electrical impedance sensors, as well as one or more ultrasound transducers or a resonant section of the stylet. The one-or-more impedance sensors can be configured to detect changes in impedance for identifying intraluminal clots in the catheter. The one-or-more ultrasound transducers can be configured for decomposing the intraluminal clots to reestablish patency in the catheter, while the resonant section of the stylet can be configured to resonate with an externally applied ultrasonic frequency for decomposing the intraluminal clots to reestablish patency in the catheter. The medical system can further include a console to which the stylet is connected in an operable state of the medical system.

The present disclosure relates generally to thrombectomy devices. An exemplary catheter comprises: a central tube; an emitter assembly mounted over the central tube, wherein the emitter assembly comprises: a conductive sheath; a first insulated wire having a first curved distal portion; and a second insulated wire having a second curved distal portion, wherein the first curved distal portion and the second curved distal portion are positioned within the conductive sheath, and wherein the emitter assembly is configured to generate a plurality of cavitation bubbles or shockwaves when a pulsed voltage is applied to the emitter assembly; and an outer tube housing the emitter assembly, wherein the outer tube is configured to receive a conductive fluid, wherein the outer tube comprises a distal opening for releasing the plurality of cavitation bubbles or shockwaves and the conductive fluid in a forward direction to treat thrombus at a treatment site.

A method of treating a mobile target tissue with a laser beam includes: providing a laser device for generating a laser beam and providing an optical fiber having a delivery end for guiding the laser beam to the target tissue; a controller causes the laser device to generate one or more laser pulses substantially along the same longitudinal axis. The controller causes the laser device to provide one or more laser pulses. The one or more pulses are selected to allow a vapor bubble formed by the one or more pulse to expand an amount sufficient to displace a substantial portion of the liquid medium from the space between the delivery end of the fiber and the target tissue. The one or more pulses are delivered to the target tissue through the vapor bubble after the vapor bubble has reached its maximum extent and has begun to collapse to reduce retropulsion of the mobile target tissue.

A wireless magnetic ultrasonic cavitation in-vivo therapeutic robotic device, including a micro-robot and an in-vitro control device; the in-vitro control device has an outer housing in which provided with electromagnetic coils and wireless power emitting coils; the micro-robot has a capsule shaped housing in which a super magnetic module is provided; a micro ultrasonic vibrator and a micro wireless power receiving coil electronically connected with each other are provided inside the housing; the wireless power emitting coils emit electromagnetic field to the micro wireless power receiving coil, which receives and then transforms the electromagnetic field to electrical current to supply power to the micro ultrasonic vibrator. The robotic device creates ultrasonic cavitation effect in the blood, causing rapid vibration of blood cells, which enhances cell regeneration power, burn blood lipids, clear blood clots and ensures good condition of blood vessels.

This invention related to manufactured microbubbles, as well as methods of using manufactured microbubbles, for example, in medicinal applications. The invention pertains to the physical structure and materials of the microbubbles, as well as to methods for manufacturing microbubbles, methods for targeting microbubbles for specific medicinal applications, and methods for delivering microbubbles in medical treatment.