Disclosed herein are apparatuses, systems, kits, and methods for treating skin, such as skin tightening or for treating diseases, disorders, and conditions that would benefit from tissue area or volume reduction, skin restoration, skin tightening, skin lifting, and/or skin repositioning and/or for generally improving skin function or appearance (e.g., the removal of unwanted skin features or irregularities such as sebaceous glands, sweat glands, hair follicles, necrosis, and fibrosis). Such apparatuses, systems, kits, and methods comprise an apparatus having a handheld main body and a detachably attachable tip comprising one or more needles.

A catheter is provided comprising localized regions of modified flexibility. The regions of modified flexibility may comprise a softened inner liner, for example softened via stretching the inner liner or disposing a plurality of holes in the inner liner, to modify the bending stiffness and/or tensile stiffness of the catheter. The catheter may further include an axially extending filament that at least partially overlaps the softened portion of the inner liner. The axially extending filament may include an anchoring section to anchor the at least one axially extending filament in a section of the catheter that includes the helical coil.

An ophthalmic medical device for separating layers of eye tissue is disclosed. The device may include a supporting structure for supporting the eye and the supporting structure may have at least one stabilizing feature that stabilizes the eye to reduce movement. The supporting structure may define at least one hollow channel for positioning a needle that is inserted into the cornea to make a fluid bubble that separates the Descemet's Membrane away from the underlying stroma. In some embodiments, the fluid bubble enables an easy, clean separation of the layers to later be transplanted in patients needing corneal transplants.

A compressed gas motor. The motor has a port and a hollow cylinder delimited by a wall with a ventilation opening, a rear closure, and a plunger axially movable in the cylinder. The plunger divides the cylinder into front and back chambers. The ventilation opening is periodically opened towards the back chamber during operation of the motor by movement of the plunger. A compression spring in the front chamber urges the plunger towards the rear closure and/or a tension spring in the back chamber draws the plunger towards the rear closure so that the back chamber is closed relative to the ventilation opening by the plunger and the back chamber is connected with the port when the same pressure prevails in the front and back chambers. The motor can be used in surgical drive systems, medical lavage systems and medical devices. Also disclosed is a method for operating the motor.

A differential pressure motor comprising two working pistons and a rod that move in a hollow space. Walls defining the hollow space have five openings. A valve piston moves between and against the working pistons and can be driven by the working pistons. The valve piston with the five openings forms a valve with which an alternate impact of a first pressure and a second pressure on the working pistons is controllable when the pressures are applied to three of the five openings such that the working pistons periodically move which drives a periodic movement of the valve piston. Also disclosed are a surgical drive system with, a medical lavage system for the debridement of soft tissue and/or bone tissue having, and a medical device for brushing, rasping or sawing soft tissue and/or bone tissue with such a differential pressure motor, and a method for operating a differential pressure motor.

A system for aspirating thrombus including an aspiration catheter having a supply lumen, an aspiration lumen, and a first connector hydraulically coupled to the proximal end of the aspiration lumen, and a pressure sensor having an internal passageway and having a distal connector configured to hydraulically couple to the first connector, a proximal connector configured to couple to a vacuum source, and a valve disposed between the distal connector and the proximal connector, the valve having an open state and a closed state.

A device for separating tissue in an eye includes a body configured to be positioned on the eye surface. The body receives air from one or more air supplies. The body includes one or more air supply channels. The separation device includes a plurality of needles extending from the body. Each needle includes a proximal opening, a distal opening, and a passageway extending between the proximal and distal openings. The proximal openings of the needles are coupled to the one or more air supply channels. The distal openings of the needles are spaced from the body to be positioned in eye tissue. The one or more air supply channels direct the air from the one or more air supplies into the proximal openings, through the passageways, and out the distal openings of the needles and into the eye tissue. The air applies a pressure to separate the eye tissue.

A system for aspirating thrombus includes an aspiration catheter including a supply lumen and an aspiration lumen each extending within an elongate shaft, and an opening at or near the distal end of the supply lumen, the opening configured to allow the injection of pressurized fluid into the aspiration lumen at or near the distal end of the aspiration lumen when the pressurized fluid is pumped through the supply lumen, a tubing set including tubing and having a distal end configured to couple to the aspiration lumen of the aspiration catheter and a proximal end configured to couple to a vacuum source, a tubing compression element configured to externally engage the tubing of the tubing set, and an activation interface configured to activate the tubing compression element to compress the tubing at a location between the proximal end of the tubing set and the distal end of the tubing set.

A system for aspirating thrombus including an aspiration catheter including a supply lumen and an aspiration lumen, the supply lumen having a proximal end and a distal end, the aspiration lumen having a proximal end and an open distal end. An opening at or adjacent the distal end of the supply lumen, in fluid communication with the interior of the aspiration lumen, is located proximally of the open distal end of the aspiration lumen. The opening is configured to create a jet when pressurized fluid is pumped through the supply lumen. A connector is hydraulically coupled to the proximal end of the aspiration lumen, the connector having an interior cavity, a proximal end and a distal end.

A method for removing thrombus from a patient, the method including providing an aspiration catheter having a supply lumen, an aspiration lumen, an opening at or adjacent a distal end of the supply lumen, and a connector hydraulically coupled to the aspiration lumen, the connector having an interior cavity. The method includes placing the aspiration catheter through an inner lumen of a guiding catheter and into the blood vessel, coupling the aspiration catheter to a fluid source and a vacuum source, causing an injection of fluid from the fluid source through the supply lumen via a first pump with the vacuum source actively coupled to the aspiration lumen, and determining that aspiration of the thrombus through the aspiration lumen is not occurring at a desired thrombus aspiration rate.