Systems and methods for delivering energy to passageways in a patient, such as airways in the lung of a patient for treating asthma. One embodiment of a method for delivering energy to a passageway comprises positioning an access device in a lung airway of a patient and advancing an elongated body of a treatment device along the access device until an energy delivery unit at a distal portion of the elongated body projects from the access device. The method can further include expanding the energy delivery unit such that energy delivery elements contact a sidewall of the airway and activating an energy supply coupled to the treatment device such that energy is delivered to the sidewall of the airway. A single person physically operates both the access device and the treatment device while expanding the energy delivery unit and activating the energy supply.

Aspects of the present disclosure are directed to flexible high-density mapping catheters with a high-density array of mapping electrodes. These mapping catheters may be used to detect electrophysiological characteristics of tissue in contact with the electrodes, and may be used to diagnose cardiac conditions, such as cardiac arrhythmias for example.

An expansion body that radially expands and contracts; an elongated shaft portion having a distal portion including a proximal end fixing portion to which a proximal end of the expansion body is fixed; a plurality of electrode portions provided along the expansion body are included, and the expansion body includes a recess portion recessed radially inward when the expansion body expands and defining a reception space that receives a biological tissue. The recess portion includes a bottom portion positioned at a radial innermost side, a proximal side upright portion extending radially outward from a proximal end of the bottom portion, and a distal side upright portion extending radially outward from a distal end of the bottom portion. One of two electrode portions that are circumferentially adjacent to each other is arranged at the proximal side upright portion, and the other is arranged at the distal side upright portion.

Systems, devices, and methods for electroporation ablation therapy are disclosed, with the system including a signal generator for generating pre-ablation signals and pulse waveforms for medical ablation therapy that may be coupled to an ablation device including at least one electrode for ablation pulse delivery to tissue. The signal generator may generate and delivery pre-ablation signals to subsets of electrodes of the ablation device and measure currents associated with the delivery to determine whether the currents meet one or more predetermined criteria. The signal generator may also generate and deliver voltage pulses to the ablation device in the form of a pulse waveform after determining that the currents meet the one or more predetermined criteria.

An ablation device and method for pulsed field ablation, the device comprising a catheter including an expandable basket, a set of electrodes formed on the expandable basket, and a pulse generator suitable for generating electric pulses wherein the pulse generator being in electrical connection with the set of electrodes. The expandable basket is formed of a braided mesh of filaments, wherein the filaments are made of nonconductive material, wherein at least portion of the filaments comprises a lumen, wherein the filaments further include electrodes and conductive wires. The conductive wires at least partially lead inside of the lumen of the filaments and are electrically connected to the electrodes.

A system for modulating bladder function is disclosed. A system for evaluating the electrophysiological function of a bladder is disclosed. Methods for performing a controlled surgical procedure on a bladder are disclosed. A system for performing controlled surgical procedures in a minimally invasive manner is disclosed. An implantable device for monitoring and/or performing a neuromodulation procedure on a bladder is disclosed.

A multiple-point basket-type or crown-shaped catheter device provides simultaneously mapping over a three-dimensional (3D) region of a subject, such as, one or more chambers of a subject's heart. The catheter device may include a series of splines each having a wave-like profile formed of a periodic series of peaks and troughs, with electrodes located at the peaks and troughs for mapping purposes.

A medical device that includes a carrier member, one or more operative components disposed in the carrier member, an optical fiber at least partly disposed in the carrier member, and at least one fiber Bragg grating (FBG) sensor array associated with the optical fiber and disposed in the carrier member. The carrier member includes an insertion end and side walls that contact the subject's body during positioning of the carrier member in the subject's body. The at least one FBG sensor array measures contact forces at one or both of the insertion end and along the side walls of the carrier member during positioning of the carrier member in the subject's body. A multi-core optical fiber configured for use in a medical device for positioning in a subject's body is also provided. A system and method for guiding positioning of a medical device in a subject's body is also provided.

Various aspects of the present disclosure are directed toward apparatuses, systems, and methods for electroporation ablation. The electroporation catheter may include an electrode assembly comprising one or more ablation electrodes configured to generate electric fields proximate to target tissue in response to a plurality of electrical pulse sequences delivered in a plurality of therapy sections, and one or more mapping electrodes configured to measure cardiac electrical signals. In some embodiments, the measured electrical signals are used to create an electro-anatomical map.

A medical system includes a catheter configured to be inserted into a body part of a living subject, and including a distal end comprising an electrode, and a processor configured to compute position coordinates of the electrode, and find a measure of proximity of the electrode to tissue of the body part responsively to the position coordinates of the electrode and position coordinates of a wall of an anatomical map of the body part.