A laser can be controlled based on different tissue compositions, such as in real time. After a first time period, a first composition of a in vivo target site can be identified. Based on the first composition, a plurality of lasers can be controlled to emit light at a first wavelength where controlling includes activating a first combination of the plurality of lasers. After a second time period, a second composition of the in vivo target site different from the first composition can be identified. Based on the second composition, a plurality of lasers can be controlled to emit light at a second wavelength, such as can include activating a second combination of the plurality of lasers. The first combination of the plurality of lasers can be different from the second combination of the plurality of lasers.

Provided herein are cranial implant devices that include at least one acoustic, optical, and/or photoacoustic lens element comprising one or more electromagnetically translucent, electromagnetically transparent, sonolucent, and/or acoustically active materials. The cranial implant devices are structured for subgaleal scalp implantation within, beneath, and/or over at least one cranial opening of a subject and typically includes a substantially anatomically-compatible shape. In addition, the cranial implant devices permit transcranial therapeutic ultrasound, transcranial diagnostic ultrasound, photoacoustic imaging, electromagnetic wave diagnostic imaging, and/or electromagnetic wave therapeutic intervention of intracranial matter of the subject via the acoustic, optical, and/or photoacoustic lens element when the cranial implant device is subgalealy implanted within, beneath, and/or over the cranial opening of the subject. Other aspects are directed to various related systems and methods of obtaining diagnostic information from, and/or administering therapy to, a subject.

A system includes a focus optic configured to converge an electromagnetic radiation (EMR) beam to a focal region located along an optical axis. The system also includes a detector configured to detect a signal radiation emanating from a predetermined location along the optical axis. The system additionally includes a controller configured to adjust a parameter of the EMR beam based in part on the signal radiation detected by the detector. The system also includes a window located a predetermined depth away from the focal region, between the focal region and the focus optic along the optical axis, wherein the window is configured to make contact with a surface of a tissue.

The optical module disclosed herein has a first lens, a second lens and an array lens arranged sequentially along the main optical axis. The first lens shapes a beam along the first direction of the main optical axis. The second lens shapes the beam along the second direction of the main optical axis. The array of array lenses is arranged along the second direction. A laser beam enters the second lens after passing through the first lens. The second lens diffuses the laser beam along the second direction. After the laser beam is converted from a Gaussian distribution to a flat-top distribution in the second direction, the laser beam is emitted through the array lens. The first direction and the second direction are perpendicular to each other.

A laminated laser window having an inner layer transparent to light having wavelengths between 3.5 micrometers and 12 micrometers and having as an outer surface a nanometric-thick outer layer of SiO2. The window allows the passage of light within this wavelength range, for example from a CO2 laser. In The SiO2 outer layer maintains biocompatibility when used in laser devices for insertion into externally accessible bodily cavities.

A laser treatment head in which an elongate applicator is shaped to access a bodily cavity. At the distal end of the applicator is a deflector protected by a window. At a proximal end of the applicator is a drive that can axially displace and rotate the applicator in a helical pattern such that laser beam pulses deflected to the mucosa area applied along a helical path to the wall of the cavity. The drive comprises a stationary hollow shaft inside a rotatable sleeve. The shaft has a helical channel in its outer surface and the sleeve has a longitudinal slot through its wall. A pin attached to the proximal end of the applicator extends through the slot and into the channel. When the sleeve is rotated, the slot advances the pin along the channel, moving the attached applicator in the helical pattern.

A system includes a focus optic configured to converge an electromagnetic radiation (EMR) beam to a focal region located along an optical axis. The system also includes a detector configured to detect a signal radiation emanating from a predetermined location along the optical axis. The system additionally includes a controller configured to adjust a parameter of the EMR beam based in part on the signal radiation detected by the detector. The system also includes a window located a predetermined depth away from the focal region, between the focal region and the focus optic along the optical axis, wherein the window is configured to make contact with a surface of a tissue.

In certain embodiments, an ophthalmic laser system comprises a laser source, multi-focal optics, scanners, delivery optics, and a computer. The laser source generates a laser beam of ultrashort laser pulses. The multi-focal optics multiplex the laser beam to yield focus spots in a target along a propagation axis of the laser beam. The scanners direct the laser beam in x, y, and z directions. The delivery optics focus the laser beam within the target to form the focus spots in the target along the propagation axis of the laser beam. The computer instructs the scanners and the delivery optics to direct and to focus the focus spots at the target according to a scan pattern.

An apparatus and method of treatment of an animal using the apparatus are disclosed. The apparatus includes a scalpel, a laser included in the scalpel, and a visible light source included in the scalpel. The visible light source provides a visible targeting beam. The method of treatment includes activating a visible targeting beam in a laser scalpel. The visible targeting beam has an illumination intensity. The method further includes illuminating a tumor that includes cancerous cells and non-cancerous cells with the visible targeting beam, activating an invisible mid-infrared laser included in the scalpel to produce a laser spot at the tumor, and ablating the cancerous cells while leaving the non-cancerous cells substantially undamaged.

A fractional handpiece and systems thereof for skin treatment include a passively Q-switched laser assembly operatively connected to a pump laser source to receive a pump laser beam having a first wavelength and a beam splitting assembly operable to split a solid beam emitted by the passively Q-switched laser assembly and form an array of micro-beams across a segment of skin. The passively Q-switched laser assembly generates a high power sub-nanosecond pulsed laser beam having a second wavelength.