The disclosed apparatus, systems and methods relate to the use of optical nanoparticles in the illumination and imaging of tissues such as cancer tissues. Optical nanoparticles such as upconverting nanoparticles can be introduced into a patient and illuminated at a first time and wavelength and then imaged at a second time and wavelength to improve resolution and reduce imager size.

A combined intraocular pressure (IOP) measuring and eye medication dispensing device may include a first micro-electro-mechanical-system (MEMS) sensor to generate IOP measurements of a living organism's eye; a medication dispensing device to dispense medication into the living organism's eye; a second MEMS micro-dispenser to interface with the medication dispensing device and to control the dispensing of the medication into the living organism's eye; and an analog-to-digital (A-to-D) converter to receive control signals. The A-to-D converter may communicate the control signals to the first MEMS sensor or the second MEMS micro-dispenser; receive the generated IOP measurements from the first MEMS sensor; receive medication dispensing parameters from the second MEMS micro-dispenser or medication dispensing device, and communicate the generated IOP measurements or the medication dispensing parameters. The device may also include a communications interface to receive the control signals from one or more processors in an external control module.

An ultrasonic tip and methods of operating the same. The ultrasonic tip comprises a shaft including a base and a flexible body. The body comprises a first portion and a second portion. The body is coupled to the base at the first portion and extends from the first portion to the second portion along a longitudinal axis. The second portion includes a cutting portion comprising a neck, and a head extending radially from the longitudinal axis. The head is coupled to the neck. A circular aperture is disposed between the head and the neck to define an inner circumferential surface. The head and the neck form an outer circumferential surface comprising a plurality of cutting teeth, the outer circumferential surface having a first thickness at the head that is greater than a second thickness at the neck.

A probe tip of an oximeter device includes first and second printed circuit boards (PCBs) that are coupled to the ends of optical fibers that transmit light between the PCBs and into patient tissue that is to be measured by the oximeter device. The PCBs are oriented at an angle between zero and ninety degrees so that the fibers have a curved shape between the locations at which the fibers are coupled to the first and second PCBs. The angular orientation of the PCBs and curved shape of the fibers allows the fibers to have a longer length than if the fibers were straight and allows for light transmitted through the fibers to have a uniform distribution across a cross-section of the fibers as the light is emitted from the fibers into patient tissue. The uniform distribution of light transmitted into patient tissue allows for reliable oximetry measurements.

In some examples, a diagnostic device includes a reusable part to receive a container of a fluid, the reusable part reusable for a plurality of diagnostic tests. The diagnostic device further includes a disposable part detachably attached to the reusable part and comprising a sample collector to collect a target sample of a living being. The diagnostic device further includes a tester comprising a fluid channel to transport the fluid to combine the fluid and the target sample to form a fluid combination, and to use the fluid combination to diagnose a condition of the target sample.

An apparatus for generating ECG recordings and a method for using the same are disclosed. The apparatus includes a handheld device having four electrodes on an outer surface thereof, the handheld device having an extended configuration and a storage configuration. The apparatus also includes a controller configured to measure signals between the electrodes to provide signals that are used to generate an ECG recording selected from the group consisting of standard lead traces and precordial traces. When the handheld device is in the extended configuration and the first and second electrodes contact a first hand of a patient such that the first and second electrodes contact different locations on the first hand, the third electrode is in contact with a location on the patient's other hand and the fourth electrode contacts a point on the patient's body that depends on the particular trace being measured.

A device (100) for measuring the amount of water in a subject's body includes a main body part (110) formed in a linear shape and an insertion part (120) extending in a curved shape from one end of the main body part (100). The insertion part (120) includes a tip side insertion part (120-2) having a tip surface (122) to which a sensor unit (121) is fixed and a base end side insertion part (120-1), wherein the sensor unit (121) is brought into contact with a body surface of a subject through a slide mechanism. A protective member (651) liquid-tightly covers the slide mechanism between the tip side insertion part (120-2) and a base end side insertion part (120-1). The protective member (651) smoothly connects the outer peripheral surface of the tip side insertion part (120-2) and the outer peripheral surface of the base end side insertion part (120-1).

A packet for a medication delivery pen comprises a pen cap integrally connected to one, some, or all of the devices listed: an unused pen needle dispenser, sharps container for used needles, folding glucose monitor, constant glucose monitor, glucose tablets/candy, lancing device, or glucose test strip holder. The integrated pen cap is configured to replace the pen cap normally supplied with the pen and the attachments and devices featured put all items needed by a diabetic in one device. This device also gives the diabetic freedom in choosing which devices they would like to or would like not to carry with them, and in what manner so as to have the highest convenience to the diabetic.

Utilization of a contact device placed on the eye in order to detect physical and chemical parameters of the body as well as the non-invasive delivery of compounds according to these physical and chemical parameters, with signals being transmitted continuously as electromagnetic waves, radio waves, infrared and the like. One of the parameters to be detected includes non-invasive blood analysis utilizing chemical changes and chemical products that are found in the conjunctiva and in the tear film. A transensor mounted in the contact device laying on the cornea or the surface of the eye is capable of evaluating and measuring physical and chemical parameters in the eye including non-invasive blood analysis. The system utilizes eye lid motion and/or closure of the eye lid to activate a microminiature radio frequency sensitive transensor mounted in the contact device. The signal can be communicated by wires or radio telemetered to an externally placed receiver. The signal can then be processed, analyzed and stored. Several parameters can be detected including a complete non-invasive analysis of blood components, measurement of systemic and ocular blood flow, measurement of heart rate and respiratory rate, tracking operations, detection of ovulation, detection of radiation and drug effects, diagnosis of ocular and systemic disorders and the like.

The present disclosure provides a device for measuring jugular venous pressure of a patient. The device comprises a body defining a longitudinal enclosure and having a window along a length of the longitudinal enclosure to allow light to exit the longitudinal enclosure, and a beam generator comprising an array of light emitters. The beam generator is configured to direct light out the window to generate a beam of light along a plane perpendicular to a longitudinal direction and at an adjustable position along the longitudinal direction. The device has an adjustment mechanism for adjusting the position of the beam of light relative to the body along the longitudinal direction, and a readout indicating the position of the beam of light along the longitudinal direction.